Answered: Why don’t all loss-of-function…

Why don’t all loss-of-function mutations that are recessive at the cellular level behave as dominants at theorganismal level? Is this property restricted to tumorsuppressor gene mutations?

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter12: Genes And Cancer

Section: Chapter Questions

Problem 1QP: Theodor Boveri predicted that malignancies would often be associated with chromosomal mutation. What...

See similar textbooks

Related questions

Q: Can nonsense mutations be reversed by hydroxylamine? Why or why not?

A: Mutations are the events that results in change in the DNA sequence. Mutations can be a result of…

Q: What is the proper route for gene delivery in different kinds of disorders?

A: Gene therapy is a promising method for correcting host pathology by the manipulation of DNA…

Q: What causes the majority of the mutations found in human melanomas and lung cancer?

A: DNA is the chemical in each cells that makes up the genes and some genes control when cells grow,…

Q: Why are some chromosomal regions amplified/deleted in a specific manner in certain tumor types?

A: Chromosomal amplification: Chromosomal amplification can be explained as the increase in the amount…

Q: Which natural genetic mechanism is responsible for preventing the expression of genes that are…

A: DNA is made up of numerous molecules known as nucleotide. A non-sense mutation is a type of mutation…

Q: What is the long term and short term effects of mutation on coding and non-coding DNA, the amount of…

A: A mutation is a change in the nucleotide sequence of an organism's genome, virus, or…

Q: How does the effect of nonsense mutation differ from that of a frameshift mutation? Why?

A: Mutations are changes that occurs in the deoxyribonucleic acid (DNA) sequence, either due to…

Q: Why are diseases due to microsatellite amplification, even though they have a monogenic pattern of…

A: The classical inheritance is the type of inheritance pattern in which mendelian laws are followed…

Q: Occasionally, a person is found who has one blue eye and one brown eye or who has a sector of one…

A: Introduction A mutation is a change in an organism's DNA sequence. Mutations can be caused by…

Q: How did the back mutation in hisG affect the protein produced by this gene?

A: Back mutation or backward mutation is a kind of mutation which leads to reversion of the mutated…

Q: Explain why loss-of-function mutations are frequently recessive, whereas gain-of-function mutations…

A: Mutation is an altered DNA sequence, which leads to changed gene product. Mutations are random and…

Q: What is a heterochronic mutation? How does it affect the phenotypic outcome of an organism? What…

A: Mutation means sudden changes occur in DNA sequences. The mutation occurs randomly. It also occurs…

Q: Define Suppressor Mutations.

A: Suppressor mutations are helpful for distinguishing new genetic sites that have an effect on a…

Q: How do translocations such as the Philadelphia chromosome contribute to cancer?

A: Translocations generate novel chromosomes, a segment from one chromosome is transferred to a…

Q: Why does a loss or an excess in genetic material lead to the expression of an abnormal phenotype?

A: Mutations are changes in the DNA sequence. Mutations can occur as a result of errors in DNA copying…

Q: What does a suppressor mutation suppress? What is the differencebetween an intragenic and an…

A: Mutation, an alteration in the genetic material of a cell of a living organism or of a virus that is…

Q: Would the pattern of segment-polarity gene expression be normal if one or more gap genes were not…

A: Segment polarity are required for patterning within each embryonic segment and mutations in genes…

Q: Certain mutations are called dominant-negative mutations. What do you think this means and how do…

A: Any kind of alteration in the nucleotide sequence of an organism’s genome is referred to as a…

Q: Why dominant negative mutation shows the haploinsufficiency ?

A: A mutation is a change that occurs in our DNA sequence, either due to mistake when the DNA is copied…

Q: Explain how DNA methylation can regulate gene expression in a tissue-specific way. When and where…

A: Introduction Expression of gene is highly under control by various mechanisms such as histone…

Q: What DNA chemical modification can change the expression level of a target gene without sequence…

A: Introduction Epigenetics refers to the heritable or non-heritable changes in gene expression,…

Q: Explain the difference between a gain-of-functionmutation and a dominant-negative mutation. Why…

A: A mutation is referred to as a change in an organism's DNA sequence. Mutations can occur as a result…

Q: What is a CpG island? Where would you expect one to be located? How does the methylation of CpG…

A: A gene is a stretch of nucleotides present in the DNA. DNA or deoxyribonucleic acid is a polymer of…

Q: According to the multi-hit model, more than one mutation must occur in a cell for cancer to develop.…

A: A new multihit model of carcinogenesis is produced for use in assessing age-explicit disease rate…

Q: What characteristics of the pedigree suggest that pancreatic cancer in this family is inherited as…

A: Introduction Pedigree Analysis: This is the new approach to study the inheritance pattern in the…

Q: Describe how mutations in genome maintenance factors promote tumorigenesis. Why would inactivation…

A: The cells are basic units of life. When any mutation in the gene takes place due to any radiation or…

Q: What is the phenotype associated with zygotic gene mutations?

A: ZYGOTE:- The male gamete "sperm" fuses with the female gamete "Ovum" and after this fusion "Zygote"…

Q: How can environmental agents that do not cause gene mutationscontribute to cancer? Would these…

A: A gene is a particular sequence of nucleotides in RNA or DNA that is generally located on a…

Q: Do you think there are more unique alleles of p53 that lead to cancer or more unique alleles of Ras…

Q: Many people with mutated alleles that are associated with diseases, including some cancers, do not…

A: A rapid change in the sequence of DNA (deoxyribonucleic acid) due to physical or chemical factors is…

Q: Why do Tbx5 mutations affect limbs and heart but no other tissues?

A: Introduction Mutation can be defined as the change in the DNA sequence or a structural change in the…

Q: what are NOTCH1 gene mutations

A: Mutations are changes occur in the DNA sequences either by environmental factors such as UV rays and…

Q: How Mutations at the Huntington disease locusare caused?

A: Huntington disease is an inherited rare disease that progressively degenerates the nerve cells…

Q: Explain why loss-of-function hedgehog and smoothened mutations yield the same phenotype in flies,…

A: The Hedgehog signalling pathway is responsible for transferring information to embryonic cells.…

Q: Are mutations that arise during mitosis or meiosis the same?

A: The genetic material consists of a nucleotide sequence that results in the expression of the…

Q: How do germ-line mutations differ from somatic mutations? Germ-line mutations are reversible, while…

A: Mutations are the random changes in the genome of organisms.

Q: Looking at mice mutations, we can see many more agouti mice that have turned albino and much less…

A: Supplementary gene In this ,the dominant allele of one of two gene governing a character produces…

Q: Mutations outside the coding sequences can modify geneexpression by altering the amount, time, or…

A: Mutations are defined as the change in the sequence of DNA of an organism due to any environmental…

Q: Explain the mechanisms of disease development that result from or cause geneexpression changes in…

A: Mutations Changes to an organism's DNA sequence . Can be the result of viral infection, exposure…

Q: A gain-of-function mutation is one in which a gene is expressed at the wrong time or in the wrong…

A: Hereditary qualities is a part of science worried about the investigation of genes, hereditary…

Q: What are three similarities and three differences between Germline mutations and Somatic mutations?

A: A mutation refers to the alteration in the sequence of DNA (deoxyribonucleic acid). It can be a…

Q: What is mutation? Distinguish between (i) neutral and silent mutation (ii) germ line and somatic…

A: Mutations can sometimes be beneficial, when they result in traits that will benefit the organism.…

Question

Why don’t all loss-of-function mutations that are recessive at the cellular level behave as dominants at the
organismal level? Is this property restricted to tumorsuppressor gene mutations?

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

This is a popular solution!

SEE SOLUTION Check out a sample Q&A here

Step 1

VIEW

Step 2

VIEW

Trending now

This is a popular solution!

Step by step

Solved in 2 steps

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.

Similar questions

Why don’t all loss-of-function mutations that are recessive at the cellular level behave as dominants at the organismal level? Is this property restricted to tumor-suppressor gene mutations?
Explain whether a cancercausing mutation in a tumorsuppressor gene, such as p53,is more likely to be a recessive ora dominant mutation.
Based on the figure below: If children with hereditary retinoblastoma often survive until adulthood and produce children, what is their risk of developing other types of tumors later in life? What is a risk for their children of developing retinoblastoma? Is there the tendency to develop retinoblastoma inherited as a dominant trait or as a recessive trait? Is there one mutant copy sufficient to predispose a person to develop the cancer or two copies are needed to develop retinoblastoma as a cancer?
What causes the majority of the mutations found in human melanomas and lung cancer?
Theodor Boveri predicted that malignancies would often be associated with chromosomal mutation. What lines of evidence substantiate this prediction?
Which natural genetic mechanism is responsible for preventing the expression of genes that are likely to contain nonsense mutations?
How can environmental agents that do not cause gene mutationscontribute to cancer? Would these epigenetic changes be passed tooffspring?
Why are oncogenes usually dominant in their action, whereas tumor-suppressor genes are recessive?
What are three similarities and three differences between Germline mutations and Somatic mutations?
Each of the four types of structural chromosomal mutations is illustrated below. Label each picture with the type of chromosomal mutation that has occurred.
Among mammals, measurements of the rate of generation of autosomal recessive mutations have been madealmost exclusively in mice, while many measurementsof the rate of generation of dominant mutations havebeen made both in mice and in humans. What do youthink is the reason for this difference?
Occasionally, a person is found who has one blue eye and one brown eye or who has a sector of one eye a different color from the rest. Can these phenotypes be explained by new mutations? If so, in what types of cells must the mutations occur?