A researcher performs an experiment where he infects 2 mice (Mouse A and Mouse B) with herpes simplex virus (HSV). To measure the cytotoxicity of CD8+ T cells from Mouse A, he isolates CD8+ T cells from Mouse A and co-cultures them with a mixture of HSV-infected spleen cells from Mouse B. A day later, he checks the co-culture, but none of the infected spleen cells from Mouse B have been killed. What could explain this observation? a.Mouse B does not express the invariant chain (Ii) b.Mouse A and Mouse B express different MHC alleles c.Mouse A does not express TLR2/6 d.HSV immunoevasins block MHC-II expression
A researcher performs an experiment where he infects 2 mice (Mouse A and Mouse B) with herpes simplex virus (HSV). To measure the cytotoxicity of CD8+ T cells from Mouse A, he isolates CD8+ T cells from Mouse A and co-cultures them with a mixture of HSV-infected spleen cells from Mouse B. A day later, he checks the co-culture, but none of the infected spleen cells from Mouse B have been killed. What could explain this observation? a.Mouse B does not express the invariant chain (Ii) b.Mouse A and Mouse B express different MHC alleles c.Mouse A does not express TLR2/6 d.HSV immunoevasins block MHC-II expression
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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A researcher performs an experiment where he infects 2 mice (Mouse A and Mouse B) with herpes simplex virus (HSV). To measure the cytotoxicity of CD8+ T cells from Mouse A, he isolates CD8+ T cells from Mouse A and co-cultures them with a mixture of HSV-infected spleen cells from Mouse B. A day later, he checks the co-culture, but none of the infected spleen cells from Mouse B have been killed.
What could explain this observation?
a.Mouse B does not express the invariant chain (Ii)
b.Mouse A and Mouse B express different MHC alleles
c.Mouse A does not express TLR2/6
d.HSV immunoevasins block MHC-II expression
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