A subset of colorectal cancers is associated with mutations in the Mut genes which code for proteins involved in repairing DNA mismatches. How would mutations in the Mut genes affect the DNA of an individual?

Q: Describe the role of mismatch repair (MMR) in DNA repair.Why do mutations in MMR proteins increase…

A: DNA mismatch repair is a system for recognizing and repairing erroneous insertion, deletion, and…

Q: In gene therapy an attempt is made to transfer a "normal" gene into the cells of a person who lacks…

A: Although gene therapy is a newer concept that has yet to be completely investigated, it has been…

Q: When UV light strikes DNA at a location where two thymines are side by side, what happens?

A: UV stands for ultraviolet rays. It causes a mutation in the DNA.

Q: Cystic Fibrosis is caused by a mutation in the CFTR gene, and an ideal form of treatment would be to…

A: Cystic fibrosis is an inherited life threatening disorder that causes severe damages to lungs,…

Q: Two types of mutations are (1) nucleotide changes and (2) unstable genome regions that undergo…

A: Given: Two types of mutation Nucleotide changes - point mutation Unstable genome regions undergo…

Q: Genes that cause cancer are called _____________.

A: Cancer means uncontrol cell proliferation and division in the body. This uncontrolled group of cell…

Q: Why might some cells in the body, such as those in bonemarrow, be more susceptible to ribosomal…

A: Mutation It is the sudden heritable changes happening in the genotype of the organism which is…

Q: What are the three main steps for repairing the DNA damages such as the deamination of cytosine…

A: Despite the elaborate proof-reading employed during DNA synthesis, erros can occur. In addition, DNA…

Q: What is the difference between a germline mutation and a somatic mutation?

A: A mutation is a biological process occurring in the Deoxyribonucleic acid (DNA) sequence due to…

Q: In cancer like disease, what kind of mutations are more focussed? Single Nucleotide Polymorphism or…

A: Introduction  Cancer is well known disease now a day. In US, 1 in 2 women and 1 in 3 men develops…

Q: What may happen to cells that accumulate a lot of DNA damage?

A: The cell is the basic structural and functional unit of the body. A cell is composed of various cell…

Q: The Effects of a Mutation are  Difficult to Predict Why?

A: A mutation is a change that occurs in the deoxyribonucleic acid (DNA)when it is damaged or changed…

Q: How might a mutation in the DNA result in the formation of cancer ?

A: The mutation is any change or alteration in the nucleotide sequence of the DNA. The mutation of a…

Q: Mutations are heritable alterations in the base sequenceof DNA.?  TRue or False

A: The genetic material can be DNA or RNA. In eukaryotes, DNA is the genetic material that is present…

Q: Which statement regarding DNA methylation and gene expression is FALSE?

A: The first option which states that none of the given options are correct (that says all the given…

Q: Why is the Philadelphia chromosome important to understanding & treating some cancers, especially…

A: Philadelphia chromosome is only present in the blood cells that are affected because of the damaged…

Q: What are neomorphic mutations?

A: Any permanent change in the DNA’s nucleotide sequence is termed as mutations. Based on their effect…

Q: n which condition does guanine-cytosine content inhibit the formation of right-handed DNA?

A: The guanine–cytosine content (or G+C content) is the percentage of nucleotides in a DNA or RNA…

Q: DNA glycosylase inhibitors are used to study which DNA repair mechanism?

A: DNA glycosylase inhibitors are used to which DNA repair mechanism?

Q: which word describes the majority of permanent genetic mutations?

A: A mutation is a change in our DNA sequence that happens as a result of errors in DNA copying or…

Q: How is DNA methylation related to cancer?

A: The alteration to the structure of chromatin affects the gene expression, which is known as…

Q: How/or which the DNA repair mechanism fixes each mutation?

A: Excision is that the general mechanism by that repairs and are created once one in every of the…

Q: Explain why p53 is mutated in the vast majority of human cancers.

A: Any isoform of a protein encoded by homologous genes in multiple animals, such as TP53 and Trp53, is…

Q: Compare and contrast DNA methylation with DNA acetylation.

A: DNA methylation: DNA methylation is a biological process that involves the addition of methyl groups…

Q: If a mutation occurs, it does not necessarily cause a genetic disease. Why?

A: The mutation is a sudden change in the DNA sequence in an organism that causes changes in nucleotide…

Q: how can breakdown in dna repair play a key role in the development of human cancers?

A: DNA can be changed by the copying errors introduced by DNA polymerase during replication.…

Q: is the action of the ultraviolet radiation on DNA to induce mutation?

A: UV radiation is a kind of non-ionizing radiation released by the sun and other artificial means. One…

Q: Explain the DNA repair defects .

A: DNA repair is a process in which cell identifies any defect in the DNA and correct it. Cells cannot…

Q: How can breakdown in DNA repair play arole in the development of human cancers?

A: One of the causative factors for cancer is the development of mutations in the genome or damage of…

Q: Patients with XP suffer extremely high incidence of skin cancer but have not been found to have…

A: There are 2 basic types of genetic mutations: Acquired mutations.  These are the most common causes…

Q: Which DNA-damage repair pathway. uses the BRCA1 and BRCA2 proteins?

A: DNA damage repair pathway is a type of DNA pathway which is used to repair the damages in the DNA…

Q: What are the two types of DNA or gene mutations

A: A mutation is a permanent change in the nucleotide sequence of DNA that can occur during replication…

Q: Select any one type of genetic mutation and explain it with the help of related Disorder?

A: A change is a modification in the nucleotide succession of the genome of a life form, infection, or…

Q: eritable effects of gene expression that are not caused by a change in DNA sequence are called…

A: EPIGENETIC CHANGES are heritable changes in gene expression that do not involve changes to the…

Q: Will cells from your liver and your brain have the same DNA fingerprint? Explain.

A: DNA fingerprinting in genetics is method is method of isolating and identifying a variable elements…

Q: Do mutations that cause cancer in an individual pass down to his/her offspring? What is the role of…

A: Cancer is the umbrella term for a group of diseases. Any of the body's cells begin to divide without…

Q: What common mutation occurs in many human cancers? Explain how it can have this effect.

A: Cancers are originated from genetic mutations. Genetic mutations are of two types; acquired and…

Q: Why are defects in DNA repair often associated with increases in cancer?

A: Any damage in the deoxyribonucleic acid (DNA) has to be repaired because this damage causes several…

Q: Why do mutations in genes that encode DNA-repair enzymes often produce a predisposition to cancer?

A: Cancer is the disease caused by loss of control over the process of cell division.

Q: What is the significance of the fact that more of the DNA is in slower-moving forms?

A: DNA (deoxyribonucleic acid) is known as molecule that include the genetic code of organisms.

Q: How can mutations in noncoding segments of DNA contribute to the development of cancers?

A: The functions segment of hereditary material that mainly codes for the proteins is a gene. The…

Q: w would mutations in the Mut genes affect the DNA of an individual?

A: A Mutation happens once a deoxyribonucleic acid cistron is broken or modified in such how on alter…

Q: Which DNA-damage repair pathway uses the BRCA1 and BRCA2 proteins?

A: BRCA1 and BRCA2 are genes that encode tumor suppressor proteins. Whenever a DNA is damaged these…

Q: Is it correct to say that the palladin gene causes cancer?

A: This palladin gene encodes a cytoskeletal protein that is required for organizing the actin…

Q: Which type of mutation results in abnormal amino acid sequence?

A: Mutation is typically the change in the sequence of the DNA. The DNA sequence of a gene can be…