Patients with XP suffer extremely high incidence of skin cancer but have not been found to have correspondingly high incidences of cancer of internal organs (e.g. colon cancer). What might this suggest about the kinds of DNA damage responsible for most internal cancers?

Q: Can we treat cancer by restoring tumor suppressor function such as mutated p53 or pRb?  If so, how…

A: The process by which a cell gives rise to two identical daughter cells is referred to as cell…

Q: How to detect cancer? What are a few approaches to treat cancer?

A: Cancer is the name that is utilized to describe the collection of related diseases. In all types of…

Q: What is the link between epigenetics and cancer?

A: Epigenetics is considered as the study in which the gene shows its behavior according to the…

Q: How can the role of epigenetics in cancer be reconciled with the idea that cancer is caused by the…

A: Epigenetics is the study of various alterations in an organism occurred because of certain gene…

Q: What causes the majority of the mutations found in human melanomas and lung cancer?

A: DNA is the chemical in each cells that makes up the genes and some genes control when cells grow,…

Q: Heavy smokers or industrial workers exposed for a limited time to a chemical carcinogen that induces…

A: Cancer is triggered by a mutation in genes, which make the fundamental physical elements of…

Q: Why is it important to model cancer through the generation of induced pluripotent stem cells ?…

A: Induced pluripotent stem cells (iPS) is a type of stem cell(pluripotent) in nature that is derived…

Q: Explain how p53 functions as a tumor suppressor gene. How can mutations in p53 lead to cancer, and…

A: Normal cell has low level of p53 protein. When DNA damage or other stress signals may trigger p53…

Q: Can we cure cancer by restoring the function of tumor suppressor proteins such as mutant p53 or pRb?…

A: Cell division is a process through which a cell produces two identical daughter cells. Cell division…

Q: Mutations in three broad classes of genes have been implicated in the onset of cancer. Can you…

A: A Mutation occurs when a DNA gene is damaged or changed in such a way as to alter the genetic…

Q: why cell injury due to genetic causes are alarmingly increasing each year.? Briefly explain at your…

A: Cell injury is the major cause which affects one body.

Q: In cancer like disease, what kind of mutations are more focussed? Single Nucleotide Polymorphism or…

A: Introduction  Cancer is well known disease now a day. In US, 1 in 2 women and 1 in 3 men develops…

Q: If cancer is fundamentally a genetic disease, how might an environmental factor such as smoking…

A: Tumor is a mass of tissues. It may be benign or malignant. The cellular growth that occurs when the…

Q: Which genetic cancer predisposition syndrome is caused by germ-line mutations in the p53 gene and is…

A: P53 is the tumor suppressor protein (TP53 in humans) which is also described as the guardian of the…

Q: A subset of colorectal cancers is associated with mutations in the Mut genes which code for proteins…

A: There are some Mut enzymes that check the identity of newly formed DNA and if there are certain…

Q: what would be the likely effect of a mutation that prevented the formation of memory cells?

A: Mutation is the sudden heritable changes that occur in the DNA sequences due to error while copying…

Q: Although tobacco smoking is responsible for a large number of human cancers, not all smokers develop…

A: Cancer refers to the uncontrolled cell division caused by the mutations in the genes which control…

Q: Unlike many other diseases, the vast majority of cancers in humans are not transmissible - meaning a…

A: Cancer is "referred" to as any abnormal growth of cell tissue. Cancer can develop anywhere in the…

Q: How do normal cells protect themselves from accumulating mutations in genes that could lead to…

A: Studies reveal that the p53 protein instructs cells to under-go apoptosis when mutations in the DNA…

Q: Explain why p53 is mutated in the vast majority of human cancers.

A: Any isoform of a protein encoded by homologous genes in multiple animals, such as TP53 and Trp53, is…

Q: (a) How does the duplication of individual genes occur? (b) individual that inherit a genetic…

A: Mutation in the DNA can change our genetic material that can causes changes in our phenotype as…

Q: How does the multistep model of cancer explain the observation that sporadic cases of retinoblastoma…

A: Disease is a sickness or illness characterized by specific symptoms and signs. Cancer is a…

Q: What would be the effect of a mutation that inactivates the p14ARF tumor suppressor upon p53…

A: p53 is known as a cellular tumor antigen 53 is a protein found in vertebrates that is responsible…

Q: Describe the underlying causes of epigenetic changes associated with cancer.

A: DNA is the genetic material in most living organisms. It is the information hub of the cell that…

Q: Do Changes in DNA cause Increased Cancer Risk ?

A: The growth of new cells and also the breaking down of the old cells generally occur by a systemic…

Q: How cancer is genetic diseases, in spite of the fact that most cancers are not inherited?

A: Cancer is a disease that involves the uncontrollable growth of some of the abnormal cells of the…

Q: how can breakdown in dna repair play a key role in the development of human cancers?

A: DNA can be changed by the copying errors introduced by DNA polymerase during replication.…

Q: Which type of mutation would NOT be involved in the inactivation of a tumor suppressor gene?

A: Normal cell growth in body is controlled by -  1. Protooncogene or cellular oncogene - Protooncogene…

Q: What role do cell check points have in cancer ?

A: Cancer is a disease that is associated with uncontrolled division of cells and invasion of…

Q: True or False: Cancers develop when many mutations develop rather than from a single mutation

A: Cancer is a genetic disease. It’s not a single disease, rather it is two or more hundreds of…

Q: How can breakdown in DNA repair play arole in the development of human cancers?

A: One of the causative factors for cancer is the development of mutations in the genome or damage of…

Q: Can restoring tumor suppressor function, such as mutant p53 or pRb, be used to cure cancer? If…

A: The Cell division is the process through which one cell divides into two identical daughter cells.…

Q: How tumor-suppressor mutations contribute to cancer?

A: Cancer - Cancer is a type of disease in which cells divide in an uncontrolled manner. The cells…

Q: Genetic instability in the form of point mutations, chromosome rearrangements, and epigenetic…

A: A mutation is a form of alteration in which a single change changes a nucleotide of nucleic acid. It…

Q: How does the normal p53 protein inhibit cancer development?

A: Tumor-suppressor genes code for proteins that repair damaged DNA (preventing a cell from turning…

Q: What evidence implicates mutagenic chemicals from the outside the body in carcinogenesis, and how…

A: Cancer is the product of a process involving complex interactions between environmental and…

Q: EXPLAIN BRIEFLY: Explain the molecular mechanisms of cancers caused by a P53 gene mutation.

A: Answers P53 also defined as tumour suppressor Gene. Hence it protect the cells from various damages…

Q: How would our understanding of this regulation affect cancer prognosis and treatment?

A: The epithelial-mesenchymal transition (EMT) is a complex developmental process that allows cancer…

Q: Radiotherapy (treatment with ionizing radiation) is one of the most effective current cancer…

A: A Radiation therapy is used to treat cancer. This therapy uses intense energy like X-rays to target…

Q: Why do mutations in genes that encode DNA-repair enzymes often produce a predisposition to cancer?

A: Cancer is the disease caused by loss of control over the process of cell division.

Q: Which are the Genetic Basis of Cancers?

A: Cancer is a disease related to abnormal growth of cells where the cells have the potential to spread…

Q: Would a drug that induced apoptosis or one that induced necrosis be preferable for treatment of…

A: INTRODUCTION Flowcytometry Flowcytometry is a technique that simultaneously measures and analyse…

Q: How is cancer different from most other types of genetic diseases?

A: Cancer is the abnormal growth and multiplication of normal cells. Cancer cell divide rapidly. Cancer…