A. What is the name of the specific sequence the scientists are measuring in the experiment shown below. B. For the individuals with lymphocyte pathology in the right panel, which gene is likely defective that causes the data shown? C. Explain why the length of the repeat sequence decreases with age.

Human Anatomy & Physiology (11th Edition)
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Chapter1: The Human Body: An Orientation
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In the experiment summarized below, scientists were examining the presence of specific sequences in individuals with age. In this experiment they extracted DNA from lymphocytes of various aged individuals and measured the length of a TTAGGG (in kb) repeat they found in their genomic DNA (Left Panel). In the right panel, the scientists measured the length of the same repeats in individuals with lymphocyte failure (red dots most severely effected) that have a mutation in a critical enzyme. Answer the following questions in 2-3 sentences each.

A. What is the name of the specific sequence the scientists are measuring in the experiment shown below.

B. For the individuals with lymphocyte pathology in the right panel, which gene is likely defective that causes the data shown?

C. Explain why the length of the repeat sequence decreases with age.

C. Explain why the length of the repeat sequence decreases with age.
TTAGGG Repeat (kb)
16
14-
12
O
CO
2
n=414
n=418
0
0 10 20 30 40 50 60 70 80 90 100
16
14
12
10
8
6
4
2
n = 89
n=121
0
0 10 20 30 40 50 60 70 80 90 100
Age (yrs)
Transcribed Image Text:C. Explain why the length of the repeat sequence decreases with age. TTAGGG Repeat (kb) 16 14- 12 O CO 2 n=414 n=418 0 0 10 20 30 40 50 60 70 80 90 100 16 14 12 10 8 6 4 2 n = 89 n=121 0 0 10 20 30 40 50 60 70 80 90 100 Age (yrs)
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