Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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All of the following are ways of controlling enzyme mechanism, except
A. Edman degradation
B. zymogens
C. phosphorylation
D. allosteric
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- Proteases are one of the main drug targets. Choose the False statement regarding proteases. A. Proteases are enzymes that cleave peptide bonds. B. Water is a reactant in the reaction catalyzed by proteases. C. Proteases, like all enzymes show substrate specificity, meaning they cleave only substate that fit the bonding product. D. Proteases rely on the proton transfer from NADH to the substrate. E. Protease mechanism involves only acid-base catalysis.arrow_forwardA small molecule is produced from a set of enzymatic reactions from a precursor substrate. It has been shown that the small molecule is able to regulate its own production. In your own words, and based on course material only: a. Identify the regulatory process and; b. Explain how this process worksarrow_forwardWhich of the following could act as one of the substrates in a reaction catalyzed by a glycosyltransferase? Choose one or more: A. GalNAc ☐ B. galactose C. UDP-GalNAc D. GDP-Mannosearrow_forward
- A single polypeptide chain houses the transferase and debranching enzyme. Cite a potential advantage of this arrangement.arrow_forwardWhich of the following is incorrect about the enzyme chymotrypsin? a. It catalyzes the addition of water across a double bond O b. It is known as a serine protease O c. Artificial substrates are used to monitor the reaction catalyzed by the enzyme d. It is classified as a hydrolasearrow_forwardDefine the following: 1. Cofactor 2. Coenzyme 3. "-ase" endingarrow_forward
- Discuss that What kind of reaction is catalyzed by each of the followingenzymes?a. citrate decarboxylaseb. oxalate reductasec. serine transaminasearrow_forwardAlthough we have introduced catalytic strategies separately, an enzyme typically employs more than one during a reaction. The catalytic strategies employed by serine protease include: Select one or more: O a. reduction of ASt b. transition state stabilization Oc. metal-assisted catalysis O d. acid/base catalysis O e. covalent catalysisarrow_forward3) Read the situations below and indicate which of the four methods of enzyme regulation is occurring for each. a) The energy-carrying molecule ATP is made by the enzyme ATP synthase. Muscle cells use a lot of energy and also have higher amounts of the ATP synthase enzyme than many other cell types. General mechanism of enzyme regulation: S b) Prostaglandins are messenger molecules involved in the inflammatory response, as well as the perception of pain. They are synthesized from polyunsaturated fatty acid substrates by an enzym called cyclo-oxygenase. "Ibuprofen" is the active ingredient in a variety of anti-inflammatory medications such as Motrin® and Advil®. It reduces pain and swelling by binding to a hydrophobic channel in the active site of cyclo-oxygenase, blocking the polyunsaturated fatty acids from binding to the enzyme, and therefore stopping production of prostaglandins. General mechanism of enzyme regulation:arrow_forward
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