Arsenate (HAsO42-) can replace inorganic phosphate (Pi) in the reaction catalyzed by glyceraldehyde 3-phosphate dehydrogenase, causing Glyceraldehyde 3-phosphate to be directly converted to 3-phosphoglycerate (NADH is still formed). If a cell is expose to Arsenate, which of the following metabolites of glycolysis will not be detectable in the cell? 2-phosphoglycerate 3-phosphoglycerate Fructose 6-phosphate Glucose 6-phosphate 1,3-bisphosphoglycerate

Arsenate (HAsO42-) can replace inorganic phosphate (Pi) in the reaction catalyzed by glyceraldehyde 3-phosphate dehydrogenase, causing Glyceraldehyde 3-phosphate to be directly converted to 3-phosphoglycerate (NADH is still formed). If a cell is expose to Arsenate, which of the following metabolites of glycolysis will not be detectable in the cell? 2-phosphoglycerate 3-phosphoglycerate Fructose 6-phosphate Glucose 6-phosphate 1,3-bisphosphoglycerate

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter23: Fatty Acid Catabolism

Section: Chapter Questions

Problem 21P: Using the ActiveModel for enoyl-CoA dehydratase, give an example of a case in which conserved...

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Based on your knowledge of the structure of NAD+ and an assumption that coenzyme dissociation is the rate limiting step of the alcohol dehydrogenase mechanism, hypothesize why a N249W mutation at the coenzyme binding site would increase the rate of catalysis.
Using the ActiveModel for enoyl-CoA dehydratase, give an example of a case in which conserved residues in slightly different positions can change the catalytic rate of reaction.
Which of the following is true about comparing the α-ketoglutarate dehydrogenase complex and the pyruvate dehydrogenase complex? Group of answer choices They catalyze reactions that produce the exact same set of products They are both dehydrogenase complexes, but have very different structures They both catalyze reactions that oxidize NADH to NAD+ They both use the same E3 enzyme component Which of the following best describes stage 2 of the citric acid cycle? Group of answer choices ATP production by the electron transport chain production of acetyl CoA regeneration of oxaloacetate release of 2 carbons as carbon dioxide
The oxidation of glyceraldehyde 3-phosphate to 1,3-bisphosphoglycerate, catalyzed by glyceraldehyde 3- phosphate dehydrogenase, proceeds with an unfavorable equilibrium constant ( K'eq= 0.08; ΔG′° = 6.3 kJ/mol), yet the flow through this point in the glycolytic pathway proceeds smoothly. How does the cell overcome the unfavorable equilibrium?
The oxidation of glyceraldehyde 3-phosphate to 1,3-bisphosphoglycerate by glyceraldehyde 3-phosphate dehydrogenase has an unfavourable equilibrium constant (K'eq= 0.08; G′° = 6.3 kJ/mol), yet the flow at this point in the glycolytic pathway is smooth. How does the cell get out of the unfavourable equilibrium?
One of the consequences of ethanol addiction is fattyliver disease, an illness in which liver cells accumulatetriacylglycerols, the esters derived from glycerol and fattyacids. Ethanol is oxidized in the cytoplasm of liver cells byalcohol dehydrogenase and aldehyde dehydrogenase to yieldacetate and 2 NADH. Acetate is then transported into themitochondrion, where it is converted to acetyl-CoA andmetabolized by the citric acid cycle. When alcohol is consumed in excessive quantities, the resulting high levels ofNADH cause metabolic abnormalities, one of which is highlevels of fatty acid synthesis. Fatty acid synthesis, also acytoplasmic process, uses acetyl-CoA as a substrate andNADPH as a reducing agent. Determine how a high level ofcytoplasmic NADH provides a source of NADPH for fattyacid synthesis.
Arsenate can replace inorganic phosphate in the reaction catalyzed by glyceraldehyde-3-phosphate dehydrogenase, causing glyceraldehyde-3-phosphate to be directly converted to 3-phosphoglycerate(NADH is still formed). Which of the following is absolutely true in case of arsenate poisoning -Glycolysis will stop - Glycolysis will still proceed with no net ATP gain - Glycolysis will not generate any form of energy - Glycolysis will still proceed, but with a net consumption of ATP - Glycolysis will proceed with lactate as end product
. Identify the Krebs cycle enzyme which acts on a five-carbon substrate, produces a four-carbon product substituent (attached to coenzyme A), and generates one molecule of NADH. a-ketoglutarate dehydrogenase pyruvate dehydrogenase citrate synthase malate dehydrogenase succinate dehydrogenase Which of the following enzymes consumes one molecule of NADH, during anaerobic fermentation in yeast, as it converts a two-carbon substrate molecule into a two-carbon product molecule? succinate dehydrogenase pyruvate decarboxylase C. isocitrate dehydrogenase lactate dehydrogenase alcohol dehydrogenase
Which of the following catalyzes a step that does NOT produce CO2? Group of answer choices alpha-ketoglutarate dehydrogenase complex malate dehydrogenase pyruvate dehydrogenase complex isocitrate dehydrogenase Citrate synthase is regulated by... Group of answer choices Concentrations of substrate and products Fructose-2,6-Bisphosphate Covalent modification Allosteric regulation by the levels of NADDH
Which of the following statements are FALSE? a A compound is an inhibitor of Glyceraldehyde 3-phosphate Dehydrogenase. If this compound were added to liver cells where D-Glucose was the only substrate one should observe an accumulation of intermediates from Glucose 6-phosphate to Glyceraldehyde 3-phosphate and a depletion of those from 1-3-Bisphosphoglyceric Acid to Pyruvate. b If the substrate for liver cells (above problem) were L-Lactate there should be no effect on the concentrations of glycolytic intermediates with the exception being a potential increase in the concentration of Pyruvate. c When Glucose is converted to lactate there is no overall change in the oxidation state because Glyceraldehyde 3-phosphate Dehydrogenase oxidizes Glyceraldehyde 3-Phosphate to 1-3-Bisphosphoglyceric Acid but Lactate Dehydrogenase reduces Lactic Acid to Pyruvate. d If all the glycolytic enzymes were added to a mixture of ATP + ADP + NAD+ and Glucose the product…
One consequence of ethanol addiction is fatty liver disease, an illness in which liver cells accumulate large amounts of triacylglycerols, the esters derived from glycerol and fatty acids. Ethanol is oxidized in the cytoplasm of liver cells by alcohol dehydrogenase and aldehyde dehydrogenase to yield acetate and 2 NADH. Acetate is then transported into the mitochondrion, where it is converted to acetyl-CoA and metabolized in the citric acid cycle. When alcohol is consumed in excessive quantities, the resulting high levels of NADH cause metabolic abnormalities, one of which is high levels of fatty acid synthesis. Fatty acid synthesis, also a cytoplasmic process, uses acetyl-CoA as a substrate and NADPH as a reducing agent. Speculate about how a high level of cytoplasmic NADH provides a source of NADPH for fatty acid synthesis.
If α-ketoglutarate is removed from TCA cycle and used to make glutamate, how many of each of the cofactors (not intermediates) and high energy molecules in the TCA cycle are lost? How much ATP does this equate to (NADH = 2.5 ATP, FADH2 = 1.5 ATP)?