Explain Why Synthesizing Glucose from Pyruvate in the Anabolic Process of Gluconeogenesis requires more energy than is captured during the Catabolic Process of Oxidizing Glucose (through glycolysis) to Pyruvate - How much of the energy (what percentage) of oxidizing Glucose to Pyruvate is captured in Catabolism as NADH (+ H+) and ATP ? - What happens to the rest of the energy of oxidizing Glucose to Pyruvate? How much energy (what percentage) is needed to synthesize Glucose from Pyruvate?

Explain Why Synthesizing Glucose from Pyruvate in the Anabolic Process of Gluconeogenesis requires more energy than is captured during the Catabolic Process of Oxidizing Glucose (through glycolysis) to Pyruvate - How much of the energy (what percentage) of oxidizing Glucose to Pyruvate is captured in Catabolism as NADH (+ H+) and ATP ? - What happens to the rest of the energy of oxidizing Glucose to Pyruvate? How much energy (what percentage) is needed to synthesize Glucose from Pyruvate?

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter19: The Tricarboxylic Acid Cycle

Section: Chapter Questions

Problem 22P: Study Figure 19.18 and decide which of the following statements is false. Pyruvate dehydrogenase is...

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Explain in bioenergetic terms how the conversion of pyruvate to phosphoenolpyruvate in gluconeogenesis overcomes the large, negative, standard free-energy change of the pyruvate kinase reaction in glycolysis.
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Complete the following description of the mechanism of the pyruvate dehydrogenase complex by using words provided. Not all words will be used. Each word will be used only one time. 5 Three enzymes of the pyruvate dehydrogenase complex work together to catalyze the production of Acetyl CoA from Pyruvate. First, a 2-carbon unit composed of Carbons # Pyruvate are added to the co-enzyme and whereas Carbon # of leaves as CO» The C-2 unit together with the co-enzyme is called transferred to the 2nd co-enzyme 11 12 The C-2 unit is then which is initially in its state. The enzyme that catalyzes this step is From here, the C-2 unit is transferred to form a linkage with CoA-SH to generate Acetyl COA Oxidized Hydroxyethyl TPP Phosphodiester Reduced Hydroxypropiony! TPP Lipoamide E-1 NADH 3 Dihydrolipoyl dehydrogenase Thioester 2 HydroxyacetyITPp Dihydropipoyl Transacetylase Type the words in the correct order separated by commas. Example: 1, 3, E-1, Thioester, Lipoamide ...
If α-ketoglutarate is removed from TCA cycle and used to make glutamate, how many of each of the cofactors (not intermediates) and high energy molecules in the TCA cycle are lost? How much ATP does this equate to (NADH = 2.5 ATP, FADH2 = 1.5 ATP)?
Complete the following description of the mechanism of the pyruvate dehydrogenase complex by using words provided. Not all words will be used. Each word will be used only one time. Three enzymes of the pyruvate dehydrogenase complex work together to catalyze the production of Acetyl CoA from Pyruvate. First, a 2-carbon unit composed of Carbons # ____ and ____ of Pyruvate are added to the co-enzyme ______ and whereas Carbon # ______ leaves as CO. The C-2 unit together with the co-enzyme is called ______ .The C-2 unit is then transferred to the 2nd co-enzyme ____, which is initially in it ___ state. The enzyme that catalyzes this step is ______.From here, the C-2 unit is transferred to form a _____ linkage with CoA-SH to generate_____
Which one of the five steps of the pyruvate dehydrogenase complex reaction is most likely to be metabolically irreversible? Explain.
Starting with pyruvate (CH3COCOO—) as the precursor, the first step of gluconeogenesis is activation of pyruvate. Show the reaction for activation of pyruvate. Name the enzyme and coenzyme for this reaction. Why is the activation step necessary? What is the next step after the activation step?
. Identify the Krebs cycle enzyme which acts on a five-carbon substrate, produces a four-carbon product substituent (attached to coenzyme A), and generates one molecule of NADH. a-ketoglutarate dehydrogenase pyruvate dehydrogenase citrate synthase malate dehydrogenase succinate dehydrogenase Which of the following enzymes consumes one molecule of NADH, during anaerobic fermentation in yeast, as it converts a two-carbon substrate molecule into a two-carbon product molecule? succinate dehydrogenase pyruvate decarboxylase C. isocitrate dehydrogenase lactate dehydrogenase alcohol dehydrogenase
During gluconeogenesis, the three irreversible steps of glycolysis have to be bypassed. The first step is the conversion of pyruvate to phosphoenolpyruvate. Which of the following statement is false regarding the reaction step? Select one: a. Conversion of oxaloacetate from pyruvate occurs in mitochondria and shuttled into the cytosol. b. Formation of phosphoenolpyruvate requires both ATP and GTP as an energy source. c. Acetyl CoA is an activator of enzyme pyruvate carboxylase. d. This reaction involves two-step process catalyzed by pyruvate carboxylase and phosphoenolpyruvate carboxykinase
Which coenzyme is most often used in dehydrogenation reactions of the type –CH2CH2- = -CH=CH- ? a) NAD b) FAD c) NADP d) FMN Which one of these transports fructose? A) GLUT-2 b) GLUT-3 c) GLUT-4 d) GLUT-5 The pyruvate dehydrogenase complex converts pyruvate to which molecule? A) oxaloacetate b) glycogen c) acetyl-CoA d) citrate The pyruvate dehydrogenase complex produces how many ATP molecules at the substrate level? A) 0 b) 1 c) 3 d) 4 The pyruvate dehydrogenase complex produces how many ATP molecules indirectly via oxidative phosphorylation per glucose molecule? A) 1 b) 3 c) 5 d) over 30