Average net charge of +2 predominates: а. b. The predominant species is +H3N-CH-((CH2)3-NH-C-NH2-NH2+)-COO- : Average net charge of arginine is 0: C.

Curren'S Math For Meds: Dosages & Sol
11th Edition
ISBN:9781305143531
Author:CURREN
Publisher:CURREN
Chapter10: Reconstitution Of Powdered Drugs
Section: Chapter Questions
Problem 7.5P
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Arginine
12
14.0
VI
12.0F
12.0
10.0F
IV
10.0
8.0
8.0
pH
6.0
6.0
4.0-
4.0
2.0
2.0
0.0
0.5
1.0
1.5
2.0
2.5
3.0
Eguiyslonts of Ou
Below you can find the titration curve for arginine. The pH was monitored, and the results
were plotted as shown in the graph. The key points in the titration are designated I to VI. For
each of the statements (a) to (f), identify the appropriate key point in the titration. (pKa
(СООН): 1.82, рКa (NH2): 8.99, pKa (R): 12.48)
Average net charge of +2 predominates:
The predominant species is +H3N-CH-((CH2)3-NH-C-NH2-NH2+)-COO- :
Average net charge of arginine is 0:
d.
а.
b.
C.
The pH is equal to the pka of the carboxyl group:
Half of the backbone amino groups are protonated:
Average net charge of arginine is +1/2:
The carboxyl group has been completely titrated:
е.
f.
g.
Transcribed Image Text:Arginine 12 14.0 VI 12.0F 12.0 10.0F IV 10.0 8.0 8.0 pH 6.0 6.0 4.0- 4.0 2.0 2.0 0.0 0.5 1.0 1.5 2.0 2.5 3.0 Eguiyslonts of Ou Below you can find the titration curve for arginine. The pH was monitored, and the results were plotted as shown in the graph. The key points in the titration are designated I to VI. For each of the statements (a) to (f), identify the appropriate key point in the titration. (pKa (СООН): 1.82, рКa (NH2): 8.99, pKa (R): 12.48) Average net charge of +2 predominates: The predominant species is +H3N-CH-((CH2)3-NH-C-NH2-NH2+)-COO- : Average net charge of arginine is 0: d. а. b. C. The pH is equal to the pka of the carboxyl group: Half of the backbone amino groups are protonated: Average net charge of arginine is +1/2: The carboxyl group has been completely titrated: е. f. g.
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