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(b) The hemoglobin subunits expressed in a growing fetus and adult mother are different from each other. The fetal y variant of the adult B subunit substitutes a Ser for one of the His residues that interacts with BPG in the central cavity between the ß subunits, reducing affinity for BPG. (i) Draw in oxygen binding curves below for the wild-type adult hemoglobin and the fetal hemoglobin containing the y variant. Make sure to label each curve. Fractional occupancy (f) lungs tissues 1.0₁ ALI 0.5- 50 pO₂ (torr) 100 (ii) Given how the mutation influences BPG binding, why do you think its advantageous for the fetus to carry this amino acid substitution? Provide a mechanistic explanation for your answer.

(b) The hemoglobin subunits expressed in a growing fetus and adult mother are different from each other. The fetal y variant of the adult B subunit substitutes a Ser for one of the His residues that interacts with BPG in the central cavity between the ß subunits, reducing affinity for BPG. (i) Draw in oxygen binding curves below for the wild-type adult hemoglobin and the fetal hemoglobin containing the y variant. Make sure to label each curve. Fractional occupancy (f) lungs tissues 1.0₁ ALI 0.5- 50 pO₂ (torr) 100 (ii) Given how the mutation influences BPG binding, why do you think its advantageous for the fetus to carry this amino acid substitution? Provide a mechanistic explanation for your answer.

Human Heredity: Principles and Issues (MindTap Course List)
Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter10: From Proteins To Phenotypes
Section: Chapter Questions
Problem 19QP: A person was found to have very low levels of functional beta globin mRNA and therefore very low...
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(b) The hemoglobin subunits expressed in a growing fetus and adult mother are different from each other. The fetal y variant of the adult ß subunit substitutes a Ser for one of the His residues that interacts with BPG in the central cavity between the ß subunits, reducing affinity for BPG. (i) Draw in oxygen binding curves below for the wild-type adult hemoglobin and the fetal hemoglobin containing the y variant. Make sure to label each curve. Fractional occupancy (f) 1.0₁ 0.5- tissues T 50 po₂ (torr) 2 lungs 100 (ii) Given how the mutation influences BPG binding, why do you think its advantageous for the fetus to carry this amino acid substitution? Provide a mechanistic explanation for your answer.
Transcribed Image Text:(b) The hemoglobin subunits expressed in a growing fetus and adult mother are different from each other. The fetal y variant of the adult ß subunit substitutes a Ser for one of the His residues that interacts with BPG in the central cavity between the ß subunits, reducing affinity for BPG. (i) Draw in oxygen binding curves below for the wild-type adult hemoglobin and the fetal hemoglobin containing the y variant. Make sure to label each curve. Fractional occupancy (f) 1.0₁ 0.5- tissues T 50 po₂ (torr) 2 lungs 100 (ii) Given how the mutation influences BPG binding, why do you think its advantageous for the fetus to carry this amino acid substitution? Provide a mechanistic explanation for your answer.
The image below depicts 2,3-bisphosphoglycerate depicted in dark gray, and ß subunits are depicted in light gray. (BPG) bound to hemoglobin. The a subunits are BPG
Transcribed Image Text:The image below depicts 2,3-bisphosphoglycerate depicted in dark gray, and ß subunits are depicted in light gray. (BPG) bound to hemoglobin. The a subunits are BPG
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