(b) The ring opening of epoxides (oxirancs) with thiols is catalysed by sodium hydroxide in aqueous media at 300 K. For a typical reaction, the pH-rate profile, between pH 8 and 14 is linear with a slope of +1. What type of catalysis is involved here - give an appropriate rcaction mechanism and state how you would establish the numerical value of the second order rate-constant for the process from the pH-rate profile. Your answer should include a definition of the term pH-rate profile and a statement of the accompanying rate equation for the process. R'-SH NaOH OH R2 Water R1-S R2

(b) The ring opening of epoxides (oxirancs) with thiols is catalysed by sodium hydroxide in aqueous media at 300 K. For a typical reaction, the pH-rate profile, between pH 8 and 14 is linear with a slope of +1. What type of catalysis is involved here - give an appropriate rcaction mechanism and state how you would establish the numerical value of the second order rate-constant for the process from the pH-rate profile. Your answer should include a definition of the term pH-rate profile and a statement of the accompanying rate equation for the process. R'-SH NaOH OH R2 Water R1-S R2

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter8: Haloalkanes, Halogenation, And Radical Reactions

Section: Chapter Questions

Problem 8.34P

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