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- Achondroplasia is a rare dominant autosomal defect resulting in dwarfism. The unaffected brother of an individual with achondroplasia is seeking counsel on the likelihood of his being a carrier of the mutant allele. What is the probability that the unaffected client is carrying the achondroplasia allele?Incontinentia pigmenti, a rare, X-linked dominant disorder inhumans, is characterized by swirls of pigment in the skin. If anaffected female, who had an unaffected father, has children with anunaffected male, what are the predicted ratios of affected andunaffected sons and daughters?A man who has color blindness and type O blood has children with a woman who has normal color vision and type AB blood. The woman’s father had color blindness. Color blindness is determined by an X-linked gene, and blood type is determined by an autosomal gene. a. What are the genotypes of the man and the woman? b. What proportion of their children will have color blindness and type B blood? c. What proportion of their children will have color blindness and type A blood? d. What proportion of their children will be color blind and have type AB blood?
- Color blindness is an X-linked genetic disorder. Choose the following genotype that represents a female with normal vision, but is a carrier of the color blind gene 1. XAY 2. XaXa 3. XAXa 4. XayA male affected with an X-linked dominant trait will have what proportion of offspring affected with the trait? a. 1/2 sons and 1/2 daughtersb. All sons and no daughtersc. All daughters and no sonsd. 3/4 daughters and 1/4 sonsA couple wish to have children, but the father has an X-linkedrecessive trait. Assuming that the mother does not carry thetrait, what percentage of their sons may inherit the trait?a. 0% d. 75%b. 25% e. 100%c. 50%
- An X-linked gene in man is for the disorder haemophilia. This is a recessive trait. Given that a woman who is a carrier of the disorder married a normal man, what is the probability of the following occurring? show COMPLETE cross. a haemophilic son______________________________ a haemophilic daughter _______________________ a normal daughter ____________________________ a normal son __________________________________Rett's syndrome is an x-linked dominant trait. Sally's father has Rett's syndrome. She has the condition, but her husband Harry does not. Their mothers were both unaffected, as was Harry's father. What is the probability that their first child will have Rett's syndrome? Group of answer choices a 50% b 0% c 75% d 25% e 100%Fragile X syndrome is an X-linked recessive Achondroplasia is an autosomal dominant trait characterized by a shortened stature. An XX individual is a carrier for Fragile X disorder and is unaffected by achondroplasia. An XY individual is not affected by Fragile X disorder and has achondroplasia. a. What is the XX individual’s genotype b. What is the XY individual’s genotype? c. If the two individuals where to have children, what are the possible genotypes and phenotypes of their children? Use a Punnett square. d. What is the probability of them having a child with Fragile X and achondroplasia?
- Hemophilia is an X-linked recessive disease. A hemophilic man marries a woman who is not a carrier of the disease. (a) Draw a Punnett square showing the genotypes of their children. (b) What are the chances that their daughters will be carriers of the disease? (c) What percentage of their children are likely to have the disease?An individual with 46, XX genotype is diagnosed with Duchenne-type Muscular Dystrophy, a recessive X-linked disorder. Genetic tests confirm that this individual is a heterozygote for this disorder. Briefly, but specifically, explain how it’s possible that they are showing symptoms of this disorder.A family has an X-linked dominant form of congenital generalizedhypertrichosis (excessive hairiness). Although the allele is dominant,males are more severely affected than females. Moreover, the womenin the family often have asymmetrical, hairy patches on their bodies.How does X chromosome inactivation explain this observation?