Below is the oxygen saturation curve for myoglobin and hemoglobin at a pH of 7. The p50 for myoglobin is indicated by the dashed lines on the graph. Mb and Hb O2 saturation: pH 7 10 0.8 Myoglobin 0.6 P50 = 0.2 0.4 Hemoglobin 0.2 - 0.0 pO2 (kPa] Which of these molecules (Mb/Hb/neither or both) has cooperativity? [ Select ] What would you expect to happen to the p50 of myoglobin if the pH were decreased to a pH of 4? [ Select ] Fraction saturation

Below is the oxygen saturation curve for myoglobin and hemoglobin at a pH of 7. The p50 for myoglobin is indicated by the dashed lines on the graph. Mb and Hb O2 saturation: pH 7 10 0.8 Myoglobin 0.6 P50 = 0.2 0.4 Hemoglobin 0.2 - 0.0 pO2 (kPa] Which of these molecules (Mb/Hb/neither or both) has cooperativity? [ Select ] What would you expect to happen to the p50 of myoglobin if the pH were decreased to a pH of 4? [ Select ] Fraction saturation

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter11: The Blood

Section: Chapter Questions

Problem 1SQE

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In addition to O2 binding, changes in other chemical conditions can result in changes in hemoglobin structure and function. Increases in blood H+ result in oxygen binding curves for hemoglobin that are shifted to the right. The effect of H+ can be understood in terms of the equilibrium:H-Hb+ + O2 → Hb-O2 + H+How does the difference in pH in the lungs and tissues help hemoglobin do its job of delivering oxygen? Use the equilibrium equation in your argument.
Which of the following conditions DOES NOT cause a “right shift” in the oxygen dissociation curve? A) A decrease in pH (increase in [H +]). B) An increase in [2,3-Di-Phosphoglycerate] (2-3, DPG concentration). C) An increase in body temperature. D) A decrease in oxygen concentration. E) An increase in CO2 concentration
The equation describing the linear relationship between hemoglobin concentration and Absorbance at 520 nm is y=0.0523x + 0.011. You can see this graph in your lab manual in the blood lab. If the absorbance value is 0.4, calculate the % Hemoglobin in whole blood You Answered 31.6% 17.95% 0.03% Correct Answer 7.43%
After spending a day or more at high altitude (with an oxygen partial pressure of 75 torr), the concentration of 2,3- bisphosphoglycerate (2,3-BPG) in red blood cells increases. What effect would an increased concentration of 2,3-BPG have on the oxygen-binding curve for hemoglobin? Why would this adaptation be beneficial for functioning well at high altitude?
You want to measure the blood oxygen level in a drop of blood using a pulse oximetry device. If you have a light source at 700nm, and 1mm of path length. What must be the concentration of, a.Oxidized hemoglobin (HbO2) concentration in blood so that the light intensity at the output decreases to the one tenth of input intensity? b. Reduced hemoglobin (Hb) concentration in blood so that the light intensity at the output decreases to the one tenth of input intensity? c.At the concentration you found in b, what is Ii / If for oxidized hemoglobin?
Which of the following is true about the T (tense) -->R (relaxed) transition of hemoglobin? A. The T state of hemoglobin binds oxygen with a higher affinity than the R state. B. The binding of O2 to a subunit T state can cause the transition of other subunits to the R state. C. The T state has a narrower pocket between b subunits than does the R state. D. When hemoglobin undergoes the T--> R transition, the structures of the individual subunits change dramatically.
Consider modeling the concentration of a chemical in a lung using the table below.Fill in the missing values and calculate the concentration at time t = 1 if the starting concentration is c0 = 0.11 mmol/L (millimoles per liter). Suppose the volume of the lung is V = 2.5 liters, the volume of air inhaled and exhaled in each breath is W =1.5 liters, and the ambient concentration of the surrounding air is a fixed 0.18 mmol/L. STEP Volume (L) Chemical (mmol) Concentration (mmol/L) Before Exhale 2.5 0.11 Exhale 1.5 0.11 After Exhale 0.11 Inhale 1.5 After Inhale The concentration at time t = 1 is c1: ______
d) Determine which statements apply to hemoglobin, myoglobin, or neither (you can write in the corresponding numbers for each statement, as appropriate) Hemoglobin Myoglobin Neither 1. Oxygen binds irreversibly to this molecule.2. This molecule has greater affinity for oxygen.3. The oxygen dissociation curve is sigmoidal in shape.4. Carbon monoxide binds at an allosteric site, lowering oxygen binding affinity.5. The binding pattern for this molecule is considered cooperative.6. This molecule delivers oxygen more efficiently to tissues.7. As oxygen binds to this molecule, the shape of the molecule changes, enhancing further oxygen binding.8. The oxygen dissociation curve is hyperbolic in shape.
Highly active muscles generate lactic acid by respiration so fast that the blood bassing through the muscle actually experiences a drop in pH from 7.4 to 7.2. Under these conditions, hemoglobin releases about 10% more O2 than it does at pH 7.4. Explain.
In the absence of 2,3-bisphosphoglycerate, the binding of oxygen by hemoglobin: a. is characterized by cooperativity b. resembles that of myoglobin c. binds at the end of the hemoglobin molecule d. is stabilized as the deoxy conformation of hemoglobin for the release into capillaries
The following graph shows partial saturation (Y) of myoglobin (Mb), adult hemoglobin (HbA) and fetal hemoglobin (HbF) as a function of partial oxygen pressure (in mmHg). Use it to answer the question: Fetal hemoglobin ( biological function: HbF) demonstrates lower p50 than adult hemoglobin (HbA). This adaptation has the following A. Allow fetal hemoglobin form pentamer subunits. B. HbF has lower affinity for for O2 compared to adult Hb C. Allow fetal hemoglobin to effectively intercept oxygen from mother's hemoglobin. D. Allow fetal hemoglobin to replace myoglobin in muscles
Which of the following stabilize the hemoglobin quaternary structure of low-affinity to oxygen molecules? Group of answer choices a. CO b. CO2 c. bisphosphoglycerate d. H+