Peptide lonization Consider a peptide with the sequence Ser-His-Glu-Cys-Arg-Gln. You will be asked to state the charge on the functional groups of this peptide at pH 1 and pH 9.5. You will also be asked to calculate the net charge on the peptide. You may find it convenient to write down the charge on each group on a piece of paper as you go along, so that you can add them up at the end. Assume the following generic pK, values for ionizable functional groups: a-carboxyl: side-chain carboxyl: imidazole: 3.1 4.1 6.0 a-amino: 8.0 thiol: 8.3 E-amino: 10.8 aromatic hydroxyl: guanidino: 10.9 12.5 At pH 9.5, the charge on the side chain of Gln is -1 +1 0.

Peptide lonization Consider a peptide with the sequence Ser-His-Glu-Cys-Arg-Gln. You will be asked to state the charge on the functional groups of this peptide at pH 1 and pH 9.5. You will also be asked to calculate the net charge on the peptide. You may find it convenient to write down the charge on each group on a piece of paper as you go along, so that you can add them up at the end. Assume the following generic pK, values for ionizable functional groups: a-carboxyl: side-chain carboxyl: imidazole: 3.1 4.1 6.0 a-amino: 8.0 thiol: 8.3 E-amino: 10.8 aromatic hydroxyl: guanidino: 10.9 12.5 At pH 9.5, the charge on the side chain of Gln is -1 +1 0.

Anatomy & Physiology

1st Edition

ISBN:9781938168130

Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble

Publisher:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble

Chapter2: The Chemical Level Of Organization

Section: Chapter Questions

Problem 39CTQ: AB+CDAD+BE Is this a legitimate example of an exchange reaction? Why or why not?

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