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- genetics, pleaseeee solve parts g and hgenetics, pleaseeee solve parts a, b and cGeneticists can synthesize any gene—any stretch of DNA—desired. Suppose you use a tree of genome evolution to predictthe structure of a now nonexistent, ancient gene. What insightsmight you obtain by synthesizing the ancient gene and insertingit into a living animal?
- The Neanderthal nuclear genome: A. Shows that Neanderthals inherited their ability to flake stone directly from Homo habilis. B. Is overwhelmingly similar to the modern human genome. C. Demonstrates once and for all that Neanderthals had language. D. Is composed exclusively of mitochondrial DNA. E. Indicates that most Neanderthal females died young, which explains why Neanderthal populations were so small.A large public and private effort went into sequencing the human genome. What did this project hope to accomplish; how did emerging technology assist the project (ie recombinant DNA, super-computing, automated sequencing), was it successful and what is the usefulness of what was learned in this massive effort?Consider three different kinds of human libraries: agenomic library, a brain cDNA library, and a livercDNA library.a. Suppose that all three of these libraries are sufficiently large so as to represent all of the differenthuman nucleotide sequences that the library couldpossibly include. Which of these libraries wouldthen correspond to the largest fraction of the totalhuman genome?b. Would you expect any of these libraries not tooverlap the others at all in terms of the sequences itcontains? Explain.c. How do these three libraries differ in terms of thestarting material for constructing the clones in thelibrary?d. Why would you need to sequence many clonesfrom many cDNA libraries to annotate a genome?
- Genomics and Human Evolution The Denisovan genome contains sequences that originated from an unknown human species. Using Figure 19.11, speculate on which species this might be. Is it possible that there are other ancestral species that may remain to be discovered that would change the phylogeny presented in the figure? FIGURE 19.11 Estimates for the dates of origin and extinction for the three main groups of hominins (green, blue, and orange). The australopithecines split into two groups about 2.7 million years ago. One of those groups, the genus Homo, contains the ancestors to our species, H. sapiens.a. Explain why the PCR is unlikely to amplify contaminatingbacterial DNA in a sample of human DNA. b. Explain how PCR could be used to pick a gene out of a complexgenome and amplify it.. Suppose that you wanted to make a genomic library to determine the complete sequence of anewly discovered organism’s genome, but you didnot have a sonicator readily available. Explain howyou could nonetheless use two or more restrictionenzymes to make libraries whose clones could besequenced so that a computer could assemble thegenomic sequence.
- An alien organism was investigated. When DNA replicationwas studied, a unique feature was apparent: NoOkazaki fragments were observed. Create a model of DNAthat is consistent with this observation.The genome of what free living organism was first fully sequenced, and when?Which goals of the Human Genome Project do you think are themost important? Why? Discuss the types of ethical problems thatmight arise as a result of identifying all of our genes.