Briefly describe the role and location of each cofactor/coenzyme involved in the pyruvate dehydrogenase reaction. The five cofactors/coenzymes are TPP, Coenzyme A, Lipoate, FAD, and NAD! Please describe their roles in pyruvate dehydrogenase reaction and where they are each located!

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Metabolic pathways

Metabolism is defined as the group of life-supporting, enzyme-mediated chemical reactions in organisms. A metabolic pathway is a set of these chemical reactions that involve anabolism (synthesis of complex biomolecules) and catabolism (breakdown of biomolecules into small molecules) that occur inside a cell. Metabolites are the reacting substances, products, and intermediate substances of an enzymatic process that are altered by a series of chemical events catalyzed by enzymes.