4.The urea cycle was the first metabolic cycle to be discovered, predating the description ofthe citric acid cycle by 5 years. Hans Krebs along with Kurt Henseleit used their Warburg manometer(pictured) to monitor the use of carbon dioxide and ammonia inthe synthesis of urea. In the presence of a slice of liver, ureacould be produced, but the reaction require ornithine andcitrulline. Since citrulline is not consumed during the course ofthe enzymatic cycle, but is rather regenerated, Krebs describedcitrulline as a "catalyst" of the process.H2NÑH2 (c)Describe the reversible steps in the urea cycle, including the substrates, products, andenzymes.(d)the urea cycle in terms of ATP equivalents? How is this cost partially offset and what is the total netenergetic cost of the urea cycle?What are the energy-consuming steps of the urea cycle and what is the energetic cost of

The urea cycle is also known as the Krebs-Henseleit Ornithine cycle. This can be described as a…

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Biology

(c) Describe the reversible steps in the urea cycle, including the substrates, products, and enzymes.

Biology: The Dynamic Science (MindTap Course List)

4th Edition

ISBN:9781305389892

Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Chapter4: Cells

Section: Chapter Questions

Problem 11TYK

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Concept explainers

Nitrogen metabolism

Nitrogen metabolism is the synthesis, utilization or uptake, breakdown, and excretion of nitrogenous compounds in the body. The nitrogen metabolism encompasses nitrogen fixation, biosynthesis, and the breakdown of amino acids, purines, and pyrimidine. Since nitrogen-containing compounds are required for various life processes, nitrogen is an important element of life.

Question

4.
The urea cycle was the first metabolic cycle to be discovered, predating the description of
the citric acid cycle by 5 years. Hans Krebs along with Kurt Henseleit used their Warburg manometer
(pictured) to monitor the use of carbon dioxide and ammonia in
the synthesis of urea. In the presence of a slice of liver, urea
could be produced, but the reaction require ornithine and
citrulline. Since citrulline is not consumed during the course of
the enzymatic cycle, but is rather regenerated, Krebs described
citrulline as a "catalyst" of the process.
H2N
ÑH2

(c)
Describe the reversible steps in the urea cycle, including the substrates, products, and
enzymes.
(d)
the urea cycle in terms of ATP equivalents? How is this cost partially offset and what is the total net
energetic cost of the urea cycle?
What are the energy-consuming steps of the urea cycle and what is the energetic cost of

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