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(c) phorylated with ATP by action of triose kinase, is there a metabolic advantage for the mole-rat to rely only on metabolism of DHAP during the period of complete anoxia with respect to the total number of ATPS generated per fructose molecule via the KHK pathway. Write the pertinent reactions in which ATP is consumed or generated using words and naming enzymes and decide whether there is a metabolic advantage over the HK pathway. Although glyceraldehyde, generated as shown from fructose-1-phosphate, can be phos-

(c) phorylated with ATP by action of triose kinase, is there a metabolic advantage for the mole-rat to rely only on metabolism of DHAP during the period of complete anoxia with respect to the total number of ATPS generated per fructose molecule via the KHK pathway. Write the pertinent reactions in which ATP is consumed or generated using words and naming enzymes and decide whether there is a metabolic advantage over the HK pathway. Although glyceraldehyde, generated as shown from fructose-1-phosphate, can be phos-

Biochemistry
Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter18: Glycolysis
Section: Chapter Questions
Problem 20P: Understanding the Mechanism of Hemolytic Anemia Genetic defects in glycolytic enzymes can have...
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It has been shown recently that the African naked GLUT5-O Fructose mole-rat can withstand up to 18 min of complete anoxia (ab- sence of O2) in the presence of high levels of CO2 without ap- parent brain damage. The basis of its capacity to tolerate such unusual conditions is that the brain, heart, and liver in the mole- rat switch to fructose-driven glycolysis. In contrast to normal mice, these tissues in the naked mole-rat have high levels of GLUT5 specific for cellular uptake of fructose. The available pathways for breakdown of fruct ose for metabolic energy production are shown on the right. KHK stands for ketohexosekinase, an enzyme that is markedly upregulated in the mole-rat compared to normal mice. Conse- quently mice must metabolize fructose largely via hexokinase (HK). In the diagram ALDOB, ALDOA, etc. represent aldolase isozymes. KHK HK Fructose-6-P PFK Fructose-1-P Fructose-1,6-BP ALDOB ALDOC ALDOA ALDOC Glyceraldehyde DHAP GAЗP Glyc-3-P 3-PGA Lactate Pyruvate mouse naked mole-rat Lactate In the study, as seen in the graphs on the right for DHAP and lactate production, it was shown with use of C-13 enriched fructose that fructose-driven glycolysis in the mole-rat resulted in faster conversion of fructose into glycolytic metabolites via the KHK pathway than via the HK pathway in mice. DHAP 1000007 8007 600- 60000- 400- 20000- 200- 30 15 Time (min) 5 15 30 Time (min) (c) phorylated with ATP by action of triose kinase, is there a metabolic advantage for the mole-rat to rely only on metabolism of DHAP during the period of complete anoxia with respect to the total number of ATPS generated per fructose molecule via the KHK pathway. Write the pertinent reactions in which ATP is consumed or generated using words and naming enzymes and decide whether there is a metabolic advantage over the HK pathway. Although glyceraldehyde, generated as shown from fructose-1-phosphate, can be phos- 13C-labeled Quantity (pmol/50mg tissue) 13C-labeled Quantity (pmol/50mg tissue) <--> ---->
Transcribed Image Text:It has been shown recently that the African naked GLUT5-O Fructose mole-rat can withstand up to 18 min of complete anoxia (ab- sence of O2) in the presence of high levels of CO2 without ap- parent brain damage. The basis of its capacity to tolerate such unusual conditions is that the brain, heart, and liver in the mole- rat switch to fructose-driven glycolysis. In contrast to normal mice, these tissues in the naked mole-rat have high levels of GLUT5 specific for cellular uptake of fructose. The available pathways for breakdown of fruct ose for metabolic energy production are shown on the right. KHK stands for ketohexosekinase, an enzyme that is markedly upregulated in the mole-rat compared to normal mice. Conse- quently mice must metabolize fructose largely via hexokinase (HK). In the diagram ALDOB, ALDOA, etc. represent aldolase isozymes. KHK HK Fructose-6-P PFK Fructose-1-P Fructose-1,6-BP ALDOB ALDOC ALDOA ALDOC Glyceraldehyde DHAP GAЗP Glyc-3-P 3-PGA Lactate Pyruvate mouse naked mole-rat Lactate In the study, as seen in the graphs on the right for DHAP and lactate production, it was shown with use of C-13 enriched fructose that fructose-driven glycolysis in the mole-rat resulted in faster conversion of fructose into glycolytic metabolites via the KHK pathway than via the HK pathway in mice. DHAP 1000007 8007 600- 60000- 400- 20000- 200- 30 15 Time (min) 5 15 30 Time (min) (c) phorylated with ATP by action of triose kinase, is there a metabolic advantage for the mole-rat to rely only on metabolism of DHAP during the period of complete anoxia with respect to the total number of ATPS generated per fructose molecule via the KHK pathway. Write the pertinent reactions in which ATP is consumed or generated using words and naming enzymes and decide whether there is a metabolic advantage over the HK pathway. Although glyceraldehyde, generated as shown from fructose-1-phosphate, can be phos- 13C-labeled Quantity (pmol/50mg tissue) 13C-labeled Quantity (pmol/50mg tissue) <--> ---->
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