, which indicates AG for each glycolytic reac- tion under intracellular conditions. Assume that glyceraldehyde-3- phosphate dehydrogenase was inhibited with iodoacetic acid. Which glycolytic intermediate would you expect to accumulate most rapidly, and why?
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- The Catabolism of Uric Acid Write a balanced equation for the oxidation of uric acid to glyoxylic acid, CO2, and NH3, showing each step in the process and naming all of the enzymes involved.Extending the Mechanism of Methylmalonyl-CoA Mutase to Similar Reactions Based on the mechanism for the methylmalonyl-CoA mutase (see problem 14), write reasonable mechanisms for the following reactions shown.Examine the ActiveModel for alcohol dehydrogenase and describe the structure and function of the catalytic zinc center.
- The Effect of lodoacetic Acid on the Glyceraldehyde-3-P Dehydrogenase Reaction (Integrates with Chapters 4 and 14.) How might iodoacetic acid affect the glyceraldehydes-3-phosphate dehydrogenase reaction in glycolysis? Justify your answer.Refer to Figure, which indicates ΔG for each glycolytic reaction under intracellular conditions. Assume that glyceraldehyde-3-phosphate dehydrogenase was inhibited with iodoacetate, which reacts with its active site cysteine sulfhydryl group. Which glycolytic intermediate would you expect to accumulate most rapidly, and why?Predict which one of the five steps of the α-ketoglutarate dehydrogenase complex reaction is metabolically irreversible under physiological conditions and explain why.
- How does an increase in the ADP/ATP ratioaffect the activity of isocitrate dehydrogenase?Predict which one of the five steps of the a-ketoglutarate dehydrogenase complex reaction is metabolically irreversible under physiological conditions and explain why.Why Alpha-Ketoglutarate dehydrogenase (a-KGDH) called deficiency? What are the probable causes? Explain.
- What structurtal property of mono- and polyunsaturated fatty acids prevents oxidation of these compounds by the β-oxidation pathway? what additional types of reactions are needed?In the complete b-oxidation of stearic acid (18:0) How many moles of acetyl CoA are produced? How many times would the fatty acid pass through the fatty acid spiral for complete oxidation?Considering that triacylglycerols get hydrolyzed in the small intestine because of pancreatic lipases, write the reactions using structural formulas by which a 7-carbon fatty acid is activated and oxidized in the liver of this patient. Indicate cofactors and underscore the final CoA products.