Genetic instability in the form of point mutations, chromosome rearrangements, and epigenetic changes needs to be maximal to allow the development of cancer. (a) With diagrams explain point mutations
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- Genetic instability in the form of point mutations, chromosome rearrangements, andepigenetic changes needs to be maximal to allow the development of cancer.(a) With diagrams explain:(i) point mutations (ii) chromosome rearrangement (iii) epigenetic changesGenetic instability in the form of point mutations, chromosome rearrangements, and epigenetic changes needs to be maximal to allow the development of cancer. (a) With diagrams explain, chromosome rearrangementCan mutation be “fixed”? What are the requirements for normal cell division? What are the requirements for cancer cells to divide and grow? Define the difference between a benign tumor, a malignant tumor, and metastatic cancer.
- What is cancer? What defects are commonly found in cancer cells? Do all cancer cells have mutations in the same genes? Explain.Define about this- Cancer Cells Contain GeneticDefects Affecting Genomic Stability ?Why is it important to model cancer through the generation of induced pluripotent stem cells ? Please list item by item. Explain in detail the main findings.
- EXPLAIN BRIEFLY: Explain the molecular mechanisms of cancers caused by a P53 gene mutation.Why does a single mutation in a proto-oncogene, turning it into an oncogene potentially lead to a cancerous phenotype, while it takes two mutations in tumor suppressor genes to lead to a cancerous phenotype?how are the hallmarks resisting cell death and enabling replicative immortality essential for cancer development. explain each in 3-5 sentences.
- Some cancers show increased incidence with age while others peak at younger ages. Whydo you suppose that some cancers have increased incidence with age while others peak inchildren?What is the difference in an oncogene and tumor suppressor gene and how can each potentially lead to cancer?Explain why p53 is mutated in the vast majority of human cancers.