Compare the structures of the fatty acids A and B below. Based on your conceptual understanding of the ATP yields from B-oxidation, which of these fatty acids do you think will yield more ATP/molecule? (I'm not asking for actual calculations in this question; rather, describe in general how the structural features of fatty acids impact overall ATP yield). a) What structural feature(s) of A suggests that it may yield more ATP than B? b) What structural feature(s) of A suggests that it may yield less ATP than B? Al А OH BI OH Now, let's test those predictions for question # 1 above. For each of the fatty acids above calculate the net yield of ATP for its complete oxidation (to CO₂) via B-oxidation, the citric acid cycle, e transport and oxidative phosphorylation. Assume that both A and B are oxidized starting from the free acids, and that 1 NADH yields 2.5 ATP and 1 FADH2 yields 1.5 ATP (also assume that NADPH is not a substrate for electron transport).

Chemistry for Today: General, Organic, and Biochemistry
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Chapter23: Carbohydrate Metabolism
Section: Chapter Questions
Problem 23.48E
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Compare the structures of the fatty acids A and B below. Based on your conceptual understanding of the ATP
yields from B-oxidation, which of these fatty acids do you think will yield more ATP/molecule? (I'm not asking for
actual calculations in this question; rather, describe in general how the structural features of fatty acids impact overall
ATP yield).
a) What structural feature(s) of A suggests that it may yield more ATP than B?
b) What structural feature(s) of A suggests that it may yield less ATP than B?
A
OH
B
OH
Now, let's test those predictions for question # 1 above. For each of the fatty acids above calculate the net
yield of ATP for its complete oxidation (to CO₂) via B-oxidation, the citric acid cycle, e transport and oxidative
phosphorylation. Assume that both A and B are oxidized starting from the free acids, and that 1 NADH yields 2.5 ATP
and 1 FADH2 yields 1.5 ATP (also assume that NADPH is not a substrate for electron transport).
Transcribed Image Text:Compare the structures of the fatty acids A and B below. Based on your conceptual understanding of the ATP yields from B-oxidation, which of these fatty acids do you think will yield more ATP/molecule? (I'm not asking for actual calculations in this question; rather, describe in general how the structural features of fatty acids impact overall ATP yield). a) What structural feature(s) of A suggests that it may yield more ATP than B? b) What structural feature(s) of A suggests that it may yield less ATP than B? A OH B OH Now, let's test those predictions for question # 1 above. For each of the fatty acids above calculate the net yield of ATP for its complete oxidation (to CO₂) via B-oxidation, the citric acid cycle, e transport and oxidative phosphorylation. Assume that both A and B are oxidized starting from the free acids, and that 1 NADH yields 2.5 ATP and 1 FADH2 yields 1.5 ATP (also assume that NADPH is not a substrate for electron transport).
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