Consider the pedigree in Figure 1. Unless there is evidence to the contrary, assume tha individuals that have married into the family do not carry the recessive gene for the trait. Aa Ar 3. 7 8 10 11 15 16 17 13 14 Figure 1. Human pedigree showing four generations. Circles represent females, and squares represent males. Shaded circles and squares represent albino individuals.
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What is the probability of cousins 12 & 16 producing an albino offspring?
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- Hemophilia and color blindness are both recessive conditions caused by genes on the X chromosome. To calculate the recombination frequency between the two genes, you draw a large number of pedigrees that include grandfathers with both hemophilia and color blindness, their daughters (who presumably have one chromosome with two normal alleles and one chromosome with two mutant alleles), and the daughters sons. Analyzing all the pedigrees together shows that 25 grandsons have both color blindness and hemophilia, 24 have neither of the traits, 1 has color blindness only, and 1 has hemophilia only. How many centimorgans (map units) separate the hemophilia locus from the locus for color blindness?A pedigree analysis was performed on the family of a man with schizophrenia. Based on the known concordance statistics, would his MZ twin be at high risk for the disease? Would the twins risk decrease if he were raised in an environment different from that of his schizophrenic brother?A proband female with an unidentified disease seeks the advice of a genetic counselor before starting a family. Based on the following data, the counselor constructs a pedigree encompassing three generations: (1) The maternal grandfather of the proband has the disease. (2) The mother of the proband is unaffected and is the youngest of five children, the three oldest being male. (3) The proband has an affected older sister, but the youngest siblings are unaffected twins (boy and girl). (4) All the individuals who have the disease have been revealed. Duplicate the counselors feat
- Given the pedigree below, answer the following questions. Note that filled symbols represent affected individuals. You assume that the allele carrying the disease is rare and therefore individuals marrying into the family are unlikely to have defective alleles. Also, assume complete penetrance. Q2) What are the genotypes of the following individuals listed in the table below? Use the uppercase “A” to represent the dominant allele and lowercase “a” for the recessive allele. Individual Genotype II-7 III-5 IV-1 IV-3 I-2 III-7Consider the pedigree below for a recessive autosomal trait caused by allele t. The dominant wild-type allele is represented by T. What is the genotype of individual 5 in generation II? A. TT or Tt B. tt C. Tt D. Tt or tt E. TTIn the pedigree attached, the shaded symbols represent people affected with a neurological disorder caused by an X-linked recessive allele. The normal allele is D and the recessive allele is d. What are the genotypes of every person in this pedigree? Please explain in as much detail as possible.
- The pedigree below shows the inheritance of the rare blistering disease (epidermolysis) in dogs. Affected individuals are indicated in black, and those not showing symptoms (phenotypically normal) of the disease in white. The pedigree below represents an autosomal recessive disease. What characteristic(s) of the pedigree supports this statement? Number the generations and individuals in this pedigree. Write the genotypes and their genotype probabilities for all the individuals in the pedigree. Use E/eas the allele symbols.An organism of the genotype AaBbCc was testcrossed to a triply recessive organism (aabbcc). The genotypes of the progeny are presented in the following table. 20 AaBbCc 20 AaBbcc 20 aabbCc 20 aabbcc 5 AabbCc 5 Aabbcc 5 aaBbCc 5 aaBbcc (a) If these three genes were all assorting independently, how many genotypic and phenotypic classes would result in the offspring, and in what proportion, assuming simple dominance and recessiveness in each gene pair? (b) Answer part (a) again, assuming the three genes are so tightly linked on a single chromosome that no crossover gametes were recovered in the sample of offspring. (c) What can you conclude from the actual data about the location of the three genes in relation to one another?What are the genotypes of the mother and father in the pedigree below? The pedigree shows albinism (an autosomal recessive trait). The shaded shapes represent albino individuals. a. mother - homozygous dominant; father - homozygous dominant b. mother - heterozygous; father - homozygous recessive c. mother - homozygous recessive; father - heterozygous d. mother - heterozygous; father - heterozygous e. mother - homozygous dominant; father - homozygous recessive
- The pedigree below is of a rare single gene disease. Given the pedigree shown below, what is the most likely pattern of inheritance for this disease? Explain your answer. Note that closed symbols are for individuals affected by the disease and open symbols are unaffected individuals (limit 3-4 sentences).The following pedigree traces the inheritance of a certain genetic disease in a family. The circles represent women and the squares represent men. Individuals with darkened shapes have the disease, while individuals with white shapes do not. The lines indicate the relationship between individuals, either through marriage or by birth. Study the chart and then answer the questions that follow. One of the people on the chart is labeled with the letter A. Which of the following statements correctly describes this person's status in the pedigree? This person does not have the disease, but this person married someone with the disease, and one of the couple's daughters has the disease as well. This person does not have the disease, but this person's father and one of this person's sisters do. This person has the disease and has two daughters with the disease.Given the pedigree below: Is the trait dominant or recessive? What are the most likely genotypes of individuals I-1 and I-2? What is the probability that individual II-2 is a carrier?