Course dashboa Time left 0:4 A single oral dose of antibiotic (500 mg) was given. The bioavailability 90%. The total amount of unchanged drug recovered in the urine was found to be 300 mg, and the total amount of metabolite recovered in the urine was 150 mg. The drug has an elimination half-life of 3.3 hr and its apparent volume of distribution is 1000 mi, Calculate the total body clearance 100 ml/hr O 190 ml/hr O 210 ml/hr 250 ml/hr

Principles of Instrumental Analysis
7th Edition
ISBN:9781305577213
Author:Douglas A. Skoog, F. James Holler, Stanley R. Crouch
Publisher:Douglas A. Skoog, F. James Holler, Stanley R. Crouch
Chapter32: Radiochemical Methods
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Problem 32.2QAP
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Course dashboa
Time left 0:4
A single oral dose of antibiotic (500 mg) was given. The bioavailability 90%. The total amount of
unchanged drug recovered in the urine was found to be 300 mg, and the total amount of metabolite
recovered in the urine was 150 mg. The drug has an elimination half-life of 3.3 hr and its apparent volume
of distribution is 1000 ml, Çalculate the total body clearance
100 ml/hr
O 190 ml/hr
O 210 ml/hr
O 250 ml/hr
Transcribed Image Text:Course dashboa Time left 0:4 A single oral dose of antibiotic (500 mg) was given. The bioavailability 90%. The total amount of unchanged drug recovered in the urine was found to be 300 mg, and the total amount of metabolite recovered in the urine was 150 mg. The drug has an elimination half-life of 3.3 hr and its apparent volume of distribution is 1000 ml, Çalculate the total body clearance 100 ml/hr O 190 ml/hr O 210 ml/hr O 250 ml/hr
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