Cyclic peptides received increasing amounts of attention because of their pharmaceutical propertie including interruption of protein-protein interactions. Please provide a mechanism for the synthesis of the cyclic peptide below from a prodrug protected linear peptide. (Amino acid R groups are simplified to A2, A3, ... as they are not participating in the reaction).

Cyclic peptides received increasing amounts of attention because of their pharmaceutical propertie including interruption of protein-protein interactions. Please provide a mechanism for the synthesis of the cyclic peptide below from a prodrug protected linear peptide. (Amino acid R groups are simplified to A2, A3, ... as they are not participating in the reaction).

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter21: Carboxylic Acid Derivatives: Nucleophilic Acyl Substitution Reactions

Section21.SE: Something Extra

Problem 35MP

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