Cystic fibrosis (CF) is a recessive autosomal disorder. In certainpopulations of Northern European descent, the number of peopleborn with this disorder is about 1 in 2500. Assuming Hardy-Weinberg equilibrium for this trait:A. What are the frequencies for the common (non-disease-causing)allele and the mutant (disease-causing) allele.B. What are the genotype frequencies of homozygous unaffected,heterozygous, and homozygous affected individuals?C. Assuming random mating, what is the probability that twophenotypically unaffected heterozygous carriers will chooseeach other as mates?

Cystic fibrosis (CF) is a recessive autosomal disorder. In certainpopulations of Northern European descent, the number of peopleborn with this disorder is about 1 in 2500. Assuming Hardy-Weinberg equilibrium for this trait:A. What are the frequencies for the common (non-disease-causing)allele and the mutant (disease-causing) allele.B. What are the genotype frequencies of homozygous unaffected,heterozygous, and homozygous affected individuals?C. Assuming random mating, what is the probability that twophenotypically unaffected heterozygous carriers will chooseeach other as mates?

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter19: Population Genetics And Human Evolution

Section: Chapter Questions

Problem 12QP

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Cystic fibrosis (CF) is a recessive autosomal disorder. In certain populations of Northern European descent, the number of people born with this disorder is about 1 in 2500. Assuming Hardy- Weinberg equilibrium for this trait: A. What are the frequencies for the normal and CF alleles? B. What are the genotype frequencies of homozygous normal, heterozygous, and homozygous affected individuals? C. Assuming random mating, what is the probability that two phenotypically unaffected heterozygous carriers will choose each other as mates?
Cystic fibrosis is an autosomal recessive disease characterized by two copies of a mutated CFTR gene. If one in 100 (hypothetical scenario, not reality) people in the United States have cystic fibrosis, calculate the p and q frequency for the normal allele (p) and the mutated allele (q). Based on those calculations, what percentage of individuals would be expected to be homozygous dominant?
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A given autosomal locus has three possible alleles (A1, A2, and A3). Assuming that the numbers of individuals with the six possible genotypes are as follows, what would be the frequency of the A1 allele in the population? A1A1 = 30 A1A2 = 27 A2A2 = 12 A1A3 = 17 A2A3 = 10 A3A3 = 4 What would be the frequency of the A3A3 genotype? Assume the population is under Hardy-Weinberg equilibrium. A. 0.182 B. 0.27 C. 0.03 D. 0.317 E. 0.107 F. 0.09
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