Identify each of the following as an example of allele, genotype, and/or phenotype frequency: A. Approximately 1 in 2500 people of Northern European descent is born with cystic fibrosis. B. The percentage of carriers of the sickle cell allele in West Africa is approximately 13%. C. The number of new mutations for achondroplasia, a genetic disorder, is approximately 5 × 10–5.

Identify each of the following as an example of allele, genotype, and/or phenotype frequency: A. Approximately 1 in 2500 people of Northern European descent is born with cystic fibrosis. B. The percentage of carriers of the sickle cell allele in West Africa is approximately 13%. C. The number of new mutations for achondroplasia, a genetic disorder, is approximately 5 × 10–5.

Human Biology (MindTap Course List)

11th Edition

ISBN:9781305112100

Author:Cecie Starr, Beverly McMillan

Publisher:Cecie Starr, Beverly McMillan

Chapter20: Chromosomes And Human Genetics

Section: Chapter Questions

Problem 6CT: About 4 percent of people of Northern European descent have a cystic fibrosis allele, but only about...

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Identify each of the following as an example of allele, genotype,and/or phenotype frequency:A. Approximately 1 in 2500 individuals of Northern Europeandescent is born with cystic fibrosis.B. The percentage of carriers of the sickle cell allele in WestAfrica is approximately 13%.C. The number of new mutations per generation resultingin achondroplasia, a genetic disorder, is approximately5 × 10−5.
If the frequency of those exhibiting a monogenic autosomal recessive phenotype caused by a rare clinically relevant allele is 1/8500 in a given population, what is the carrier frequency? Please give your answer as a percentage to 3 decimal places, do not include the % symbol. ANSWER: In a population where the frequency of those exhibiting a monogenic autosomal recessive phenotype caused by only one known mutation is 1/8500 the carrier frequency is a percent.
Consider the case of a hypothetical genetic disease called WhySciEleven (WSE), an inherited disease that results to the inability to complete production of an amino acid “moduleactivity” that results in brain damage if untreated. WSE is due to a recessive allele. Given one WSE occurrence per 10,000 births. Which term in the Hardy-Weinberg equation corresponds to the frequency of individuals who have no alleles for the disease WSE? a. p b. 2pq c. p2 d. q2
Cystic fibrosis is an autosomal recessive disease characterized by two copies of a mutated CFTR gene. If one in 100 (hypothetical scenario, not reality) people in the United States have cystic fibrosis, calculate the p and q frequency for the normal allele (p) and the mutated allele (q). Based on those calculations, what percentage of individuals would be expected to be homozygous dominant?
Repeat this process for the following genotypic frequencies for the presence or absence of mid-digital hair by a typical 1407 class: Frequency of homozygous dominants (HH, mid-digital hair present): 0.21 Frequency of heterozygous individuals (Hh, mid-digital hair present): 0.16 Frequency of homozygous recessives (hh, no mid-digital hair): 0.63 Total No. of alleles present: _____________ Number of dominant alleles possessed by homozygous dominants: _____________ Number of recessive alleles possessed by homozygous recessives: _____________ Number of dominant alleles possessed by heterozygotes: _____________ Number of recessive alleles possessed by heterozygotes: _____________ Total number of dominant alleles in the population: _____________ Frequency of the dominant allele (H) in the population: _____________ Frequency of the recessive allele (h) in the population: _____________
Alkaptonuria is a recessive autosomal genetic disorder associated with darkening of the urine. In the United States, approximately 1 out of every 250,000people has alkaptonuria.a. Assuming Hardy-Weinberg equilibrium, estimatethe frequency of the allele responsible for this trait.b. What proportion of people in the U.S. populationare carriers for this trait? In this population, whatis the ratio of carriers to individuals affected byalkaptonuria?c. If a woman without alkaptonuria had a child withthis trait with one husband then remarried, what isthe chance that a child produced by her secondmarriage would have alkaptonuria?d. Alkaptonuria is a relatively benign condition, sothere is little selective advantage to individualswith any genotype; as a result, your assumptionof Hardy-Weinberg equilibrium in part (a) is reasonable. Could you also use the assumption ofHardy-Weinberg equilibrium to estimate the allelefrequencies and carrier frequencies of more severerecessive autosomal conditions…
Cystic fibrosis (CF) is a recessive autosomal disorder. In certain populations of Northern European descent, the number of people born with this disorder is about 1 in 2500. Assuming Hardy- Weinberg equilibrium for this trait: A. What are the frequencies for the normal and CF alleles? B. What are the genotype frequencies of homozygous normal, heterozygous, and homozygous affected individuals? C. Assuming random mating, what is the probability that two phenotypically unaffected heterozygous carriers will choose each other as mates?
In the genetics unit you learned that sickle cell anemia is an autosomal recessive condition. In 2016, assume in the City of Markham there are 1000 people out of 300000 people who have sickle cell anemia. Assume global warming continues for the next 50 years and in the year 2066 there are 20000 people out of 500000 in Markham who have sickle cell anemia. a)What are the allele frequencies in 2016? What are the allele frequencies in 2066? Is microevolution evident? b)Due to global warming, assume the numbers of malaria carrying mosquitoes in Markham dramatically increased between 2016 and 2066. What do you believe is the main cause of the microevolution in Markham? (Hint- refer to the 5 factors affecting microevolution and refer back…
It has been hypothesized that people who are heterozygous for the allele that causes the deadly genetic condition cystic fibrosis (which, among other symptoms, reduces fertility) are more resistant to the deadly disease tuberculosis. Question - if the cystic fibrosis allel protects against tuberculosis the same what the sickle cell allele protects against malaria, then which of the following should be true in comparison between regions with or with out TB. -cystic fibrosis deaths should be more common in regions with tb - CYSTIic fibrosis deaths should be less common in regions with tb - CYSTIic fibrosis deaths should be equally common in regions with tb -Regional differences in the cystic fibrosis death rate should be purly random and upredictable.
In humans, Rh-positive individuals have the Rh antigen on their red blood cells, while Rh-negative individuals do not. If the Rh-positive phenotype is produced by a dominant gene (A), and the Rh-negative phenotype is due to its recessive allele (a), what is the frequency of the Rh-positive allele if 84% of a population is Rh-positive?
In humans, the genetic disease cystic fibrosis is caused by a recessive allele (a). The normal (healthy) allele is dominant (A). What is the genotype of someone who has cystic fibrosis? What are the two different genotypes that a healthy person could have? If two people were both heterozygous for the cystic fibrosis gene, what fraction of their children would be likely to have this disease? Hint: Draw a Punnett square to figure it out.
A pedigree analysis was performed on the family of a man with schizophrenia. Based on the known concordance statistics, would his MZ twin be at high risk for the disease? Would the twins risk decrease if he were raised in an environment different from that of his schizophrenic brother?