Cystic fibrosis is a genetic disease that causes an abnormal production of mucus which in turn can cause damage and infection to the lungs and other organs. In the following pedigree, black indicates all those persons afflicted with cystic fibrosis (square symbols are males, circles are females). There's a healthy couple and they have two children. One is a 23-year-old daughter with cystic fibrosis who is married to a 24-year-old male who is healthy. The other child is a 15-year-old son who is healthy After studying the pedigree, write a logical hypothesis suggesting the cause of cystic fibrosis in terms of dominant or recessive alleles.  On the basis of your hypothesis, write an appropriate genotype for both of the  parents.  Using a Punnett square, what is the probability of the parents having a child with cystic fibrosis?  If the daughter's husband is a carrier of cystic fibrosis, what is the probability that they have a child with cystic fibrosis? Show your Punnett square.

Medical Terminology for Health Professions, Spiral bound Version (MindTap Course List)
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ISBN:9781305634350
Author:Ann Ehrlich, Carol L. Schroeder, Laura Ehrlich, Katrina A. Schroeder
Publisher:Ann Ehrlich, Carol L. Schroeder, Laura Ehrlich, Katrina A. Schroeder
Chapter3: The Skeletal System
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Cystic fibrosis is a genetic disease that causes an abnormal production of mucus which in turn can cause damage and infection to the lungs and other organs. In the following pedigree, black indicates all those persons afflicted with cystic fibrosis (square symbols are males, circles are females). There's a healthy couple and they have two children. One is a 23-year-old daughter with cystic fibrosis who is married to a 24-year-old male who is healthy. The other child is a 15-year-old son who is healthy

  1. After studying the pedigree, write a logical hypothesis suggesting the cause of cystic fibrosis in terms of dominant or recessive alleles. 
  2. On the basis of your hypothesis, write an appropriate genotype for both of the  parents. 
  3. Using a Punnett square, what is the probability of the parents having a child with cystic fibrosis? 
  4. If the daughter's husband is a carrier of cystic fibrosis, what is the probability that they have a child with cystic fibrosis? Show your Punnett square. 
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