d) Figure 10 shows DNA fingerprinting method carried out to detect the rightful father of a child. Children Father 1 Father 2 Father 3 10.000bp 1,000 bp Figure 10 i) Who would most likely be the father of this child? State your reason. .... ..................... . ...... ...... ...... ...... ..... | || || | |
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- Neither Tim nor Rhoda has Duchenne muscular dystrophy, but their firstborn son does. What is the probabilitythat a second child will have the disease? What is theprobability if the second child is a boy? A girl?. For several years, Hans Nachtsheim investigated an inherited anomaly of the white blood cells of rabbits. Thisanomaly, termed the Pelger anomaly, is the arrest ofthe segmentation of the nuclei of certain white cells. Thisanomaly does not appear to seriously burden the rabbits.a. When rabbits showing the Pelger anomaly were matedwith rabbits from a true-breeding normal stock,Nachtsheim counted 217 offspring showing the Pelgeranomaly and 237 normal progeny. What is the geneticbasis of the Pelger anomaly?b. When rabbits with the Pelger anomaly were matedwith each other, Nachtsheim found 223 normal progeny,439 with the Pelger anomaly, and 39 extremely abnormalprogeny. These very abnormal progeny not only haddefective white blood cells, but also showed severedeformities of the skeletal system; almost all of themdied soon after birth. In genetic terms, what do yousuppose these extremely defective rabbits represented?Why were there only 39 of them?c. What additional experimental evidence…Why can't you determine your exact genotype if you have a bent little finger
- Stefan has launched a paternity suit to determine whether he is the father of an orphan residing in a monastery. Can mitochondrial DNA be used to trace the paternity? Explain.Unattached earlobes (E) are dominant over attached earlobes (e) [Figure (a) and (b)]. If a woman with unattached earlobes and a man with attached earlobes have children, what percentage of their children has the possibility of having unattached earlobes if the mother is homozygous for the trait?A young couple went to see a genetic counselor because each had a sibling with cystic fibrosis. (Cysticfibrosis is a recessive disease, and neither member ofthe couple nor any of their four parents is affected.)a. What is the probability that the female of thiscouple is a carrier?b. What are the chances that their child will havecystic fibrosis?c. What is the probability that their child will be acarrier of the cystic fibrosis disease allele?
- A couple who are about to get married learn from studying their family histories that, in both their families, theirunaffected grandparents had siblings with cystic fibrosis(a rare autosomal recessive disease).a. If the couple marries and has a child, what is theprobability that the child will have cystic fibrosis?b. If they have four children, what is the chance that thechildren will have the precise Mendelian ratio of 3:1 fornormal:cystic fibrosis?c. If their first child has cystic fibrosis, what is theprobability that their next three children will be normal?How come the conclusion came to be as half of the son and none of the daughter have precorious puberty? Can you use a cross?The percentage chance that the mother described above will give birth to a daughter with mid-digital hair and freckles is what percentage?
- Which blood type phenotypes (A, B, AB, and/or O) provide anunambiguous genotype? Is it possible for a couple to produce afamily of children in which all four blood types are represented? Ifso, what would the genotypes of the parents have to be?If diseases such as cardiovascular disease (hypertension and atherosclerosis) are familial, is this an indication that there is a genetic contribution to these traits? What would you do to confirm that genetics is involved in this condition?Cystic fibrosis is an autosomal disease that mainly affects the white population, and 1 in 20 whites are heterozygotes. Genetic testing can diagnose heterozygotes. Should a genetic screening program for cystic fibrosis be instituted? Should the federal government fund it? Should the program be voluntary or mandatory, and why?