Despite the failure to date of gene therapy, identification of the gene responsible for cystic fibrosis has very recently led to effective treatments for the disease in patients with particular mutant alleles. Give an example?

Q: Why are the correct primer sequences essential for successful amplification?

A: Polymerase chain reaction (PCR) is a widely used method in molecular biology that is used to make…

Q: What is an exconjugant? How do you think that exconjugants were obtained? (It might include genes…

A: Answer: Introduction: Conjugation is the process of transfer of DNA from one bacterium to other by…

Q: How can we be sure that the insertion of the therapeutic gene does not harm some other necessary…

A: The Food and Drug Administration still has not approved any human gene therapy product. Current gene…

Q: though the treatment of patients with ADA with gene therapy was encouraging, what is needed to…

A: Gene therapy is one of the most effective emerging methods of treatment. However, it is still not a…

Q: How can researchers pinpoint the particular driver mutations most responsible for the cancer…

A: The development of cancer is an evolutionary process at the cellular level. Several mutations…

Q: Should freely available access to genetic databases, including genomes, and gene or protein…

A: The NCBI (National centre of biotechnology information) is the center of all the databases and these…

Q: Why are bone marrow stem cells ideally suited as targets for gene therapy?

A: Bone marrow stem cells are widely suited as targets for gene therapy because they provide two major…

Q: Explain the use of a marker gene ?

A: Gene is a functional unit of heredity. Marker genes are those genes which are added along with a…

Q: From the data, what can you conlucde about the effect of this mutant?

A: The difference between tyrosine and phenylalanine is that tyrosine has an hydroxyl group. The liver…

Q: Would the application of paclitaxel to a cell make us incapable of performing karyotyping on that…

A: Karyotyoing is the process by which DNA is analyzed . The chromosome structure is usually studied .

Q: Mammography is an accurate screening technique for the earlydetection of breast cancer in humans.…

A: Cancer is a devastating medical condition characterized by the growth of abnormal cells in the body…

Q: explain why gene mapping is important and how this technique can be used in disease investigation?

A: The Human Genome Project aimed at developing tools to identify new genes and their function. Genetic…

Q: Compare and contrast the use of histochemical reporter genes and fluorescent reporter genes — what…

A: Reporter genes can be analyzed by different methods, such as beta glucuronidase (uidA) gene…

Q: Why is the Philadelphia chromosome important to understanding & treating some cancers, especially…

A: Philadelphia chromosome is only present in the blood cells that are affected because of the damaged…

Q: Describe the medical applications of human gene therapy in the following diseases: Haemophilia,…

A: Gene therapy is a treatment of a disease where the genetic material is transferred into human cells.…

Q: When parents with sickle cell anemia plan to have kids, they would consult a genetic counselor for…

A: Genetic counseling uses

Q: To maximize the number of mutations following UV irradiation, should you incubate the irradiated…

A: A mutation is a modification that happens in the deoxyribonucleic acid (DNA) sequence, either due to…

Q: Why is it that somatic gene therapy is allowed in many countries and yet germ-line gene therapy is…

A: Gene therapy is a technique in which genes are used for the prevention and treatment of disease.…

Q: "Genome-Wide Association Studies Identify Genome Variations That Contribute to Disease" Explain this…

A: The genome-wide association comprises scanning all the marker genomes or complete sets of DNA to…

Q: What is/are the role/s of molecular techniques in understanding cancer? Cite some references from…

A: In cancer, cells grow abnormally. Cancer is not one disease. It is a group of diseases. The…

Q: Give a diagram of how we can treatment the Cystic fibrosis by using gene therapy?

A: A new, correct form of the CFTR gene would be implanted into a person's cells as part of gene…

Q: Discuss why a genetic disease might have a particular age of onset.Would an infectious disease have…

A: Different genetic diseases result in different abnormalities in the human genome. A genetic disorder…

Q: Discuss two reasons why the therapeutic use ofembryonic stem cells can present a problem.

A: The embryonic stem cells are pluripotent cells that possess the ability to differentiate into any…

Q: Are genome and karyotype instabilities consequencesor causes of cancer?

A: Genome ad karyotype instabilities really leads to cancer.Lets have a detailed discussion: Genome…

Q: When doing a lab that involves Extraction of Genomic DNA from adult Drosophila melanogaster. - What…

A: Drosophila melanogaster, known colloquially as the fruit fly, remains one of the most commonly used…

Q: What class of mutations do you think would be less likely to lead to CF? Please explain your…

A: Cystic fibrosis is a genetic disease caused by mutations in a single CFTR gene that lead to abnormal…

Q: Why is mutation breeding necessary for breeding for disease resistance?

A: Breeding is defined as sexual reproduction occurring between two organisms of the opposite sex of…

Q: Discuss the advantages and disadvantages of using bacterial system instead of Mammalian system to…

A: Bacterial systems biology is the systematic and integrative study of the functions and properties of…

Q: (a) How does the duplication of individual genes occur? (b) individual that inherit a genetic…

A: Mutation in the DNA can change our genetic material that can causes changes in our phenotype as…

Q: MCR1 the only gene responsible for the variation in the human skin color?

A: MCR1 (melanocortin 1 receptor)  gene is very well known to be associated with the variations found…

Q: A disease "D" is caused by a combination of genetic and environmental factors. Polymorphisms in…

A: In the progression of the disease and pathogenesis of disease-causing agents genetic and…

Q: Explain the advantage of the systems biology approachto studying cancer versus the approach of…

A: System biology is used in the preparation of complex biological systems based on the interactions…

Q: Please distinguish driver and passenger mutations in cancer.

A: Driver mutations: Mutations in known oncogenes that help cells establish or maintain the transformed…

Q: What is a notch 3 gene mutation test?

A: Notch is a cell surface receptor that receives and transmits signals in notch signalling pathway. It…

Q: While a great deal of information can be gleaned from aging studies using cells in culture, why…

A: Aging is a complicated process that is driven by both environmental and inherent genetic factors.…

Q: During the first successful gene therapy trial in which Ashanti DeSilva was treated for SCID, did…

A: Gene therapy is the process by which defective or non-functional gene can be replaced by a normal…

Q: Explain the following figure. According to this model, what are the two major phases of metastasis…

A: The figures tells about the metastasis. Metastasis is the spread of cancer cells to the healthy or…

Q: Sequencing the human genome, the development of microarray technology, and personal genomics promise…

A: To describe: How are Sequencing the human genome, the development of microarray technology, and…

Q: Because cancer cells do not normally die, does this imply that if people attempted to extend their…

A: In many ways, cancer cells differ from normal cells in the body. Normal cells become malignant when…

Q: Would you consider the “smoking-lung cancer relationship” as an example of the biological…

A: almost 10 lakh people die due to lung cancer every year. 90% and 85% of men and women have lung…

Q: the role of X-gal? What color will cells with the plasmid be in the absence of X-gal? Why?

A: X- gal refers to the organic compound which comprises a galactose associated with an indole group.…

Q: Hello! Discuss the onco-suppressive function of xenophagy + ( role of adaptors, compare and contrast…

A: Xenophagy is the process of consuming and digesting foreign cells or material. This can happen in…

Q: What is a gene knockout? Is an animal or plant with a gene knockout a heterozygote or homozygote?…

A: Genes are the basic structural and functional unit of heredity. They carry coded genetic information…

Q: Is it correct to say that the palladin gene causes cancer?

A: This palladin gene encodes a cytoskeletal protein that is required for organizing the actin…

Q: In the gene therapy trials for SCIDS, what DNA was added to the patients’ cells? Could this same…

A: "Severe combined immunodeficiency" (SCID) is an X-linked disorder of the immune system that occurs…

Tissue regeneration & repair

Tissue regeneration involves the restoration of tissue components by regrowth of damaged tissues. In contrast, tissue repair involves patching of injured tissue rather than restoring it. It is the proliferative capacity of the cells that decides the amount of regeneration against the repair that would occur in the tissue. Both regeneration and repair depending on the duration of the injury and response to the inflammation.