though the treatment of patients with ADA with gene therapy was encouraging, what is needed to conclude that this approach should become a andard of care that would be used for all patients with ADA?
Q: w a diagram that shows how we can treatment Hemophilia by using gene therapy? Please draw at your…
A: Hemophilia is a recessive X-linked illness.This condition is caused by a lack of clotting factor…
Q: The nurse is explaining the general goal of gene therapy to a patient. With gene therapy, the…
A: Gene therapy is the new treatment technique for many diseases. However, it is not approved as…
Q: How can we be sure that the insertion of the therapeutic gene does not harm some other necessary…
A: The Food and Drug Administration still has not approved any human gene therapy product. Current gene…
Q: Discuss the importance of proteomics in the developmentof treatments for genetic disorders.
A: Omics is the branch of science that deals with the technological approach. This helps to explore the…
Q: Explain the Retroviral vectors of Gene Therapy ?
A: Retrovirus is used to infect the mammalian cells as they used host cells to multiply. Retrovirus is…
Q: What is one stumbling block in AAV gene therapy in some patients?
A: Biotechnology is technology that utilizes biological systems, living organisms or parts of this to…
Q: Distinguish between a gene knockout versus a gene replacement,and describe how both are used in the…
A: Gene can be defined as the basic physical and functional unit of heredity. Genes are made up of DNA.…
Q: What kinds of diseases do gene and cell therapy treat?
A: Gene therapy is employed a large range of diseases, like cancer, SCID, heart disorders, hemophilia…
Q: What is the difference between gene therapy and cell therapy?
A: A therapy, also known as a medical treatment, is an attempt to address a medical problem after a…
Q: Explain an example of a successful gene therapy trial. In your answer be sure to consider: a…
A: SCID is a genetic disorder caused by numerous genetic mutations which are characterized by the…
Q: Should freely available access to genetic databases, including genomes, and gene or protein…
A: The NCBI (National centre of biotechnology information) is the center of all the databases and these…
Q: A genetic profile cana. assist an individual in maintaining good health.b. be accomplished utilizing…
A: Genetic profile - It is the most effective technique to distinguishing between two individual and…
Q: What are the considerations for choice of a vector in gene therapy?
A: HIV consists of single-stranded RNA in the replication form that has been transcribed into…
Q: Who should be treated by gene therapy?
A: In molecular biology, gene therapy is defined as the insertion of DNA into the patient in order to…
Q: Will genome editing emerge as the safest and most reliablemethod of gene therapy, rendering other…
A: Genome editing is an advanced molecular technique where the DNA sequences are altered through the…
Q: . In selecting target cells to receive a transferred gene in gene therapy in an adult person, what…
A: To cure some of the human diseases gene therapy can be given to the patient. Gene therapy is the…
Q: explain why gene mapping is important and how this technique can be used in disease investigation?
A: The Human Genome Project aimed at developing tools to identify new genes and their function. Genetic…
Q: What are the different approaches to gene and cell therapy? What risks are associated with gene and…
A: Biotechnology is a wide space of science, including the utilization of living frameworks and organic…
Q: What Genetic Conditions Are Candidates for Treatment by GeneTherapy?
A: The Genetic Conditions Are Candidates for Treatment by Gene Therapy are: • These cells can be…
Q: What advantages do bioengineered organs have over donor transplants? If you had a failing organ and…
A: The application of engineering in the field of biology and medicine is called bioengineering. It…
Q: Can someone give me a few inherited disorders that are NOT caused by mutations? and if possible,…
A: Tay Sachs disease- Children's with the tay Sachs disease appears healthy at birth but becomes…
Q: What percentage of cells in an organ or a tissue need toexpress a therapeutic gene to alleviate the…
A: Gene therapy is the method that involves the insertion of DNA or sequence of DNA in the cells of the…
Q: Why is it that somatic gene therapy is allowed in many countries and yet germ-line gene therapy is…
A: Gene therapy is a technique in which genes are used for the prevention and treatment of disease.…
Q: Compare and contrast ex vivo and in vivo gene therapy as approaches for delivering therapeutic…
A: Viral vectors are used as carriers for normal genes that replace the defective genes within the…
Q: pick a specific disease that is currently a candidate for gene therapy—(a)briefly describing the…
A: Gene therapy aims at treating the disease at the molecular level, by modifying the genetic material…
Q: What is the role of a vector in gene therapy?
A: Gene therapy is based on the premise that replacement of a disease-causing gene with the healthy…
Q: Name any one disease for which gene therapy has been proved effective?
A: Gene therapy is one of the treatment methods to treat genetic diseases. It involves the replacement…
Q: what is a current disease that cannot be tackled and how would you use the human genome project and…
A: Genomics advances pertinent to human wellbeing and illness incorporate data about the human genome…
Q: Define the Ethical Concerns Surrounding Gene Therapy ?
A: In gene therapy mutated gene is replaced by a healthy gene. The ethical issue (EI) includes:- Who…
Q: For what reasons would gene therapy be more effective performed onembryos rather than fully…
A: Gene therapy is a broad field in recombinant technology where specially designed genes are used to…
Q: Despite the failure to date of gene therapy, identification of the gene responsible for cystic…
A: Cystic fibrosis (CF) is a genetic disease caused by a mutation in the CFTR (cystic fibrosis…
Q: What are the implications of resistance gene transfer for the future practice of medicine?
A: Bacteria multiply quickly and have a variety of methods for exchanging DNA. This is how they are…
Q: Give a schematic diagram of how we can Treatment Cystic fibrosis by using gene therapy?
A: Cystic disorder is a form that causes disorders in lungs, digestive system and other organs. It is…
Q: In selecting target cells to receive a transferred gene in gene therapy, what factors do you think…
A: Gene therapy involves transferring of cloned genes into target cells by the process of recombinant…
Q: During the first successful gene therapy trial in which Ashanti DeSilva was treated for SCID, did…
A: Gene therapy is the process by which defective or non-functional gene can be replaced by a normal…
Q: Explain some barriers that must be overcome before gene therapy becomes a safe, practical,…
A: it is the introduction of the DNA with the desired gene in order to cure disease this correct the…
Q: In selecting target cells to receive a transferred gene in gene therapy, what factors do you think…
A: Gene Therapy --- Gene therapy is defined as an experimental technique in which uses of genes to…
Q: What are the potential concerns regarding the use of viral vectors in gene therapy?
A: Introduction :- Gene therapy is the process of changing the genes in your body's cells in order to…
Q: Which vector is used to replace the defective gene in gene therapy?
A: Gene therapy focuses on utilizing the nucleic acids as a drug to treat cancer and other genetic…
Q: Ashanti Silva received the first gene therapy for the treatment of SCID. What do you think, would…
A: Severe combined immunodeficiency is a group of rare disorders caused by mutations in different genes…
Q: Give examples of effective and ineffective gene therapy. Describe each and discuss in 150 words
A: Gene therapy is a process in which the underlying disease present in the genes can be corrected by…
Q: Draw a diagram of how we can treatment the Sickle cell anemia by using gene therapy? Please draw at…
A: Gene therapy is a technique that modifies a person's genes to treat or cure disease. Gene therapy in…
Q: Why has gene therapy not been the success that was expected when it was first proposed as a viable…
A: Introduction:- Gene therapy includes modifying genes within the body's cells to treat or prevent…
Q: How can genomics be used to predict disease risk and treatment options?
A: Genes are the segments of DNA that regulate a particular genetic trait.
Q: What are the potential hazards of gene therapy?
A: Introduction: Gene therapy is a branch of medicine that focuses on genetically altering cells to…
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- Induced pluripotent stem cells have allowed scientists to model various diseases and screen drugs in these in vitro models. Please provide information on induced pluripotent stem cells and their use as described above (model various diseases and screen drugs in these in vitro models). Please explain clearly and nicely. THANKSThe prospect of using gene therapy to alleviate genetic conditions is still a vision of the future. Gene therapy for adenosine deaminase deficiency has proved to be quite promising, but many obstacles remain to be overcome. Currently, the correction of human genetic defects is done using retroviruses as vectors. For this purpose, viral genes are removed from the retroviral genome, creating a vector capable of transferring human structural genes into sites on human chromosomes within target-tissue cells. Do you see any potential problems with inserting pieces of a retroviral genome into humans? If so, are there ways to combat or prevent these problems?Cellular reprogramming and induced pluripotent stem cells have allowed scientists to model various diseases and screen drugs in these in vitro models. Please select a disease that can be modeled through the generation of induced pluripotent stem cells. 1) a drug that has been screened in this disease model. Explain in detail the main findings.
- The human intestinal tract is home to a vast, diverse microbial community. The bacteria that comprise this microbial community serve a number of important, beneficial functions. However, some bacterial species have been suggested to play a role in certain forms of cancer. One such bacteria is Fusobacterium nucleatum (i.e., F. nucleatum). Investigators wishing to study the role of F. nucleatum in colorectal cancer developed a new assay for detecting these bacteria in tumor tissue. In controlled experiments, the test was highly sensitive in detecting F. nucleatum and also had high specificity. To examine consistency in their test findings, the investigators also conducted repeat tests in 50 tissue samples. From these repeat tests, the investigators observed that the overall number of samples in which F. nucleatum was detected was almost identical (10 out of 50 on the first test vs. 11 out of 50 on the repeat test); for 9 samples, F. nucleatum was detected on both the initial and the…A student said, “The approach shown by the Chicago researchers is just conventional gene therapy with biomaterial carrier”. Is he or she correct? Why? based on “Targeted polyelectrolyte complex micelles treat vascular complications in vivo”, PNAS 2021, Vol. 118 No. 50 e2114842118;107:110210; https://doi.org/10.1073/pnas.2114842118Which of the following best describes the approach that wasused in the first gene therapy trial for treating SCID?a. The normal ADA gene was introduced by injecting liposomesdirectly into the patients’ bodies. b. Lymphocytes were removed from a SCID patient, the normalADA gene was transferred into the lymphocytes vialiposomes,and then the lymphocytes were returned to thepatient’s body.c. Lymphocytes were removed from a SCID patient, the normalADA gene was transferred into the lymphocytes via a retrovirus,and then the lymphocytes were returned to thepatient’s body.d. None of the above describe the approach used in the trial.
- The journal article "On the rapidity of antibiotic resistance evolution facilitated by a concentration gradient [See #1 for reference]" used the methods of "Mutational pathway determines whether drug gradients accelerate evolution of drug-resistant cells [See #2 for reference]". Reference used #1 : Hermsen, R., Deris, J. B., & Hwa, T. (2012). On the rapidity of antibiotic resistance evolution facilitated by a concentration gradient. Proceedings of the National Academy of Sciences, 109(27), 10775–10780. doi:10.1073/pnas.1117716109 #2 : Greulich, P., Waclaw, B., & Allen, R. J. (2012). Mutational Pathway Determines Whether Drug Gradients Accelerate Evolution of Drug-Resistant Cells. Physical Review Letters, 109(8). doi:10.1103/physrevlett.109.0881 QUESTIONS: 1. Based on Biological and Science manner, what is your comment/feedback on how the research articles/author presented their used material and methods?BiDil® is indicated for the treatment of heart failure as an adjunct to standard therapy in self-identified black patients to improve survival, to prolong time to hospitalization for heart failure, and to improve patient-reported functional status Question: The results of BiDil® clinical trials were compelling…Expound on the results. Question : What role did FDA’s approval resulted in BiDil® being a great example of pharmacogenomics/pharmacogenetics in the U.S.?Genetic information has become part of our culture and it is difficult to tell the difference between unmodified and genetically modified food sources such as plant and animals. After reading this module’s material regarding vectors in biotechnology, consider the potential for nanotechnology and scientific advancement.Research nanotechnology and its potential use in biotechnology. In one or two paragraphs, explain the potential advantages and disadvantages of nanotechnology in health care, agriculture, or industry and discuss whether you would or would not support further research.
- step 1 Staphylococcus aureus is a bacteria, that is now resistant to commonly used antibiotics, and it is now resistant to the antibiotic methicillin (narrow spectrum beta lactam class). step 2 Describe the physiological mechanism used by individual bacteria to resist the antibiotic listed in above of this Thought Question. For example, the mechanism could be modification of drug, modification of target, prevention of drug penetration, overproduction of target, or target mimicry. (This means that you must choose a strain of bacteria that we know the characteristic of the bacteria that allows the bacteria to be resistant.)Which of the following statement is false regarding the SARS-CoV-2 protease Mpro? a) Mpro catalyze the translation of viral RNA into polyproteins b) Mpro is an ideal drug target because its structure is largely conserved across the SARS-CoV family c) N3 is an irreversible inhibitor that block the substrate binding site of Mpro d) Mpro forms a dimeric structure and each protomer is composed of three domainsResults from a Kirby Bauer antibiotic assay on a Gram-negative bacterial culture are described as follows: A) the bacterium is resistant to penicillin, an antibiotic that targets synthesis of the peptidoglycan cell wall and B) the bacterium is resistant to tetracycline, an antibiotic that targets the small subunit of the ribosome, inhibiting protein synthesis. Which of the results represents intrinsic resistant and which represents acquired resistants?