Determine the pl for this synthesized pentapeptide: A-B-C-D-E Given that the pK values for the amino acids in the peptide are Amino Acid pK1 pK2 pKR 2.38 9.55 1.96 9.83 3.53 C 2.97 10 2.15 9.88 E 2 9.02 5.13 Give your answer to 2 places after the decimal.

Organic Chemistry
9th Edition
ISBN:9781305080485
Author:John E. McMurry
Publisher:John E. McMurry
Chapter26: Biomolecules: Amino Acids, Peptides, And Proteins
Section26.6: Peptide Sequencing: The Edman Degradation
Problem 13P
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Determine the pl for this synthesized pentapeptide: A-B-C-D-E
Given that the pK values for the amino acids in the peptide are
Amino
pK1 pK2 pKR
Acid
A
2.38 9.55
B
1.96 9.83 3.53
C
2.97 10
D
2.15 9.88
E
9.02 5.13
Give your answer to 2 places after the decimal.
Assume that acidic pKr are carboxy groups and basic pKr are amino
groups.
Transcribed Image Text:Determine the pl for this synthesized pentapeptide: A-B-C-D-E Given that the pK values for the amino acids in the peptide are Amino pK1 pK2 pKR Acid A 2.38 9.55 B 1.96 9.83 3.53 C 2.97 10 D 2.15 9.88 E 9.02 5.13 Give your answer to 2 places after the decimal. Assume that acidic pKr are carboxy groups and basic pKr are amino groups.
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