Doc -2 Therapeutic Drugs Doc-1-Introduction: Specific applicati ons of genetic engineening are abundant & increase rapidly especially in production of medications (pharmaceuticals proteins). The application of recombinant proteins in medications minimizes the risk of transmitting infections which used to happen in the past upon consuming proteins purified from animal tissues. Recombinant proteins are safer as well because unlike animal proteins, they are not recognized as foreign molecules by the immune system, and as a result they don't cause all ergy. In this lesson, we will identify the method of insulin production for therapeutic use. Doc-2- Insulin Production Insulin is a protein functions in reducing the glucose level in the blood In some patients, there is deficiency in insulin, so they depend on exogenous insulin to control their blood glucose level. In past, scientists used anim als like horses & rabbits to produce insulin, this caused allergy in some cases & it was expensive, moreover it was being produced in low amounts. Nowadays, thanks for biotechnol ogy. insulin is produced in high amounts, in less time, in low costs and with no nisk for any allergy. The applied experimental procedure in pro ducing recombinant proteins is the same one adapted for gene cloning except that the gene of interest is now specified. a- Translate the procedure into a text. The plasmid is extracted and then cleaved with restriction enzyme The insulin producing bacteria are cultured for proliferation E.coli C The plasmid is reintroduced to obtain recombinant bacteria The insulin gene is inserted into the plasmid Insulin is isolated and purified from the bacteria The insulin gene is isolated from a human cell Production of protein ( Human insulin) by Genetic Engincering The insulin is administered to a patient with diabetes Dac-3- Advantages (Benefts): L Economic Value - It is produced in high am ounts. - It is produced in less time. - It is less expensive (low cost). Medical Value - It is used as a medicati on by diabetic patients. - It is healthy, safe & doesn't cause allergy. 130
Doc -2 Therapeutic Drugs Doc-1-Introduction: Specific applicati ons of genetic engineening are abundant & increase rapidly especially in production of medications (pharmaceuticals proteins). The application of recombinant proteins in medications minimizes the risk of transmitting infections which used to happen in the past upon consuming proteins purified from animal tissues. Recombinant proteins are safer as well because unlike animal proteins, they are not recognized as foreign molecules by the immune system, and as a result they don't cause all ergy. In this lesson, we will identify the method of insulin production for therapeutic use. Doc-2- Insulin Production Insulin is a protein functions in reducing the glucose level in the blood In some patients, there is deficiency in insulin, so they depend on exogenous insulin to control their blood glucose level. In past, scientists used anim als like horses & rabbits to produce insulin, this caused allergy in some cases & it was expensive, moreover it was being produced in low amounts. Nowadays, thanks for biotechnol ogy. insulin is produced in high amounts, in less time, in low costs and with no nisk for any allergy. The applied experimental procedure in pro ducing recombinant proteins is the same one adapted for gene cloning except that the gene of interest is now specified. a- Translate the procedure into a text. The plasmid is extracted and then cleaved with restriction enzyme The insulin producing bacteria are cultured for proliferation E.coli C The plasmid is reintroduced to obtain recombinant bacteria The insulin gene is inserted into the plasmid Insulin is isolated and purified from the bacteria The insulin gene is isolated from a human cell Production of protein ( Human insulin) by Genetic Engincering The insulin is administered to a patient with diabetes Dac-3- Advantages (Benefts): L Economic Value - It is produced in high am ounts. - It is produced in less time. - It is less expensive (low cost). Medical Value - It is used as a medicati on by diabetic patients. - It is healthy, safe & doesn't cause allergy. 130
Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter16: Reproductive Technology, Genetic Testing, And Gene Therapy
Section: Chapter Questions
Problem 18QP
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