Draw a structural formula for each amine and amine derivative. (a) N,N-Dimethylaniline (b) Triethylamine (c) tert-Butylamine (d) 1,4-Benzenediamine (e) 4-Aminobutanoic acid (f) (R)-2-Butanamine (g) Benzylamine (h) trans-2-Aminocyclohexanol (i) 1-Phenyl-2-propanamine (amphetamine) (j) Lithium diisopropylamide (LDA) (k) Benzyltrimethylammonium hydroxide (Triton B)

Q: (1) Which is the most basic amine and which is a secondary amine? (2) Which can undergo hydrolysis?…

A: Given (1) Which is the most basic amine and which is a secondary amine? (2) Which can undergo…

Q: 1. Which are the starting materials used to synthesize the given compound through reductive…

A:

Q: Treating trimethylamine with 2-chloroethyl acetate gives acetylcholine as its chloride.…

A: Trimethylamine reacts with 2-chloroethylacetate by SN2 mechanism. Thus the bond breaking and bond…

Q: Show how to prepare the following aromatic amines by aromatic nitration, followed by reduction. You…

A: The following c) m-bromoaniline (d) m-aminobenzoic acid can be prepared by aromatic nitration,…

Q: Reduction of ethyl nitrile using H2/Ni produces a.1-propanamine b.propanamine c.ethanamine…

A: Q.1 reduction of ethylnitrile (CH3CN) using H2/Ni gives  Q.2 Reduction of nitrobenzene and it's…

Q: Give reasons for the following:(i) Aniline does not undergo Friedal-Crafts reaction.(ii) (CH3)2 NH…

A: Friedal-Crafts reaction is an electrophillic substitution of aromatic ring with an alkyl halide and…

Q: Show how to prepare the following aromatic amines by aromatic nitration, followed by reduction. You…

A: Preparation of c) m-bromoaniline :  Benzene is taken as the starting material. The correct sequence…

Q: The reaction of an amide with aqueous strong acid produces a(n). A) carboxylic acid and an ammonium…

A: The compounds in which -CONH- group and -COOH group is present are called amide and carboxylic acid,…

Q: In the 1880's, Acetanilide, sold under the name Antifebrin, was widely used as a pain reliever and…

A: Here we have to write the mechanism of acid catalyzed hydrolysis of acetanilide and synthesis of…

Q: Why are tertiary amines more basic than primary and secondary amines? Because tertiary amines are…

A: Chemical compounds are classified on the basis of attached functional groups. The compounds…

Q: 3. Suggest convenient methods of preparation of each of the following compounds from readily…

A: Interpretation -  To prepare the each of following compounds which is given above in the question by…

Q: The hydrolysis of an amide in acidic conditions forms       A. a carboxylate salt and an alcohol…

A: Given :  The hydrolysis of an amide in acidic conditions forms

Q: The two most general amine syntheses are the reductive amination of carbonyl compounds and the…

A: Amines are the compounds that have NH2 group present in it. The lone pair of nitrogen can be donated…

Q: A. The water solubility of amines found in medications can be increased by salt formation.…

A: The atomic number of nitrogen is 7. It belongs to the p-block of the periodic table. In order to…

Q: Following is a series of anorexics (appetite suppressants). As you study their structures, you will…

A: An anorexia is a drug which causes loss of appetite that leads to weight loss. There are a numerous…

Q: Rank the following compounds in order of increasing basicity: L p-nitroaniline H.…

A: Basicity of a molecule is the tendency to donate the lone pair of electrons. Electron withdrawing…

Q: Explain the mechanism for the acid catalyzed hydrolysis of an amide?

A: Amides are the chemical compounds that are obtained by the condensation reactions of carboxylic and…

Q: Which of the following amines would be best chosen for preparing an enamine derivative from…

A: Aldehyde and ketone in presence of an acid reacts with secondary amines to give enamine . So the…

Q: Reduction of an alkyl azide results in the formation of —-. A. an imine B. an oxime C. a tertiary…

A: Alkyl azide have general formula R-N3

Q: Show how to synthesize the following amines from the indicated starting materials.(a)…

A: Given reactions,    (a) N-cyclopentylaniline from aniline    (b) N-ethylpyrrolidine from pyrrolidine

Q: Explain why a secondary amine forms a nitrosamine rather than a diazonium ion when it reacts with a…

A: Given reaction is:

Q: Rank the following compounds in order of increasing basicity: I. p-nitroaniline II.…

A:

Q: „CHO NH3 H2. Ni A -H20 60 °C, 90 atm CI

A: Since the N in NH3 is having lone pair electron and C attached to O in the benzene reactant is…

Q: The following rearrangement reactions give a primary amine EXCEPT: A. Hoffmann B. Lossen C. Curtius…

A: Except Beckmann all option s give primary amine. Beckmann convert ketone to amide

Q: Indicate whether the following statement is true or false. Aliphatic amines are more basic than…

A: Amine is the derivative of ammonia .

Q: Prozac may be prepared via a Mannich reaction using which amine? Benzylamine Methylamine Ethylamine…

A: A chemical reaction in which organic compounds take part is called organic reactions.  Organic…

Q: Reduction of aromatic nitro-compounds using Sn and HCl gives :Select one a. aromatic secondary…

A: Given, Reduction of aromatic nitro compounds using Sn and HCl gives = ? Sn/HCl - is a reducing agent…

Q: (a) Draw the structures of the following compounds :(i) 4-Chloropentan-2-one…

A: To draw the structures of below compounds (i) 4-Chloropentan-2-one (ii) p-Nitropropiophenone To give…

Q: By discussing the basicities of the amine structures given below, list the basicities from large to…

A: Basicity of amine basically depends upon the number of the groups or atoms attached to the nitrogen…

Q: Following are structural formulas for two more widely used sulfonylurea hypoglycemic agents.Show how…

A: To synthesize Gliclazide, diethyl carbonate can be treated with the hydrazine to make the carbamic…

Q: 3. Rank the following primary amines (anilines in this case) in order of increasing basicity (1 =…

A: Basicity - Basicity is the property of compound that tells us how much baisc that compound is and…

Q: Show how to prepare the following aromatic amines by aromatic nitration, followed by reduction. You…

A: The structure of p-bromoaniline is shown below.

Q: In the following reactions, compounds A and B are the major products obtained in each of them.…

A: Esterification involves the formation of ester from acid and alcohol.

Q: Following is a series of anorexics (appetite suppressants). As you study their structures, you will…

A: A synthesis for a given  compound has to be given, The given compound is,

Q: Show how to synthesize the following amines from the indicated starting materials below. Each of the…

A: Trimethylsulfonium iodide in the presence of strong base reacts with ketone to produce epoxide.…

Q: In the mid-1930s a substance was isolated from a fungus that is a parasite of ryes and other…

A: Given that, lysergic acid diethylamide (LCD, C20H25N3O). It is a weak base, having Kb = 7.6×10-7.…

Q: The name of following amine H3C-CH3 compound is N-methylbenzeneamine, and it is a tertiary aliphatic…

A:

Q: (a). Benzphetamine is a habit-forming diet pill sold under the trade name Didrex. It is prescribed…

A: Stereogenic carbon has 4 different atoms or groups attached to it Hoffman elimination gives less…

Q: Although acetanilide and phenacetin are not appreciably acidic, aceta- minophen (like aspirin) is a…

A: Carboxylic acids and phenols are acidic than water. These react with sodium hydroxide to form sodium…

Q: Treatment of pentanedioic (glutaric) anhydride with ammonia at elevated temperature leads to a…

A: In this question, we will draw the structure of the Product which molecular formula is C5H7NO2  You…

Q: 3 Compare the basicity of amines with other common bases, and explain how theirbasicity varies with…

A: SOLUTION: Step 1: Amines are basic because they possess a pair of unshared electrons, which they can…

Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.