Answered: Explain the High frequency of the…

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Explain the High frequency of the sickle-cell allele HbβS in regions of Africa where malaria is prevalent?

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter19: Population Genetics And Human Evolution

Section: Chapter Questions

Problem 2CS: If allele frequencies in the hemoglobin gene are influenced by sickle cell anemia on the one hand...

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Concept explainers

Hematology

Hematology is the branch of biology. Hematology is the medical field that deals with the treatment of blood disorders and cancers, such as hemophilia, leukemia, lymphoma, and sickle-cell anemia. Hematologists and hematopathologists are medical professionals who specialize in illnesses of the blood and its components.

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Explain the High frequency of the sickle-cell allele HbβS in regions of Africa where malaria is prevalent?

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In recent years, the country of Zambia in Africa has had increasing cases of malaria. If 9% of the population is born with a severe form of sickle-cell anemia (ss), what percentage of the population will be more resistant to malaria because they are heterozygous (Ss) for the sickle-cell gene, under the Hardy-Weinberg assumption?
What would happen to the frequency of heterozygous carriers of sickle-cell anemia (with AS genotype) if mosquitoes were completely wiped out in a large region?
Do you think the allele for sickle cell anemia would be common in regions where malaria did not exist? Explain why or why not.
What impact might a vaccine against malaria have on the frequency of the Sickle Cell allele in Africa in the long run?
What is the heterozygous advantage of people having sickle-cell trait in areas where malaria is a major cause of death?
Why does sickle cell anemia remain more prevalent in Sub-Saharan Africa than in the rest of the world? a. Reduced access to medical facilities presidposes Sub-Saharan Africans to an increased chance od disease. b. The prevalence of malaria in Sub-Saharan Africa provided a selective advantage to individuals who were heterozygous. c. Infection with malaria provides a selective disadvantage to individuals who are heterozygous for the sickle cell allele. d. People of African ancestry are genetically predisposed to carry the sickle cell allele
Humans who are born homozygous for the recessive sickle cell allele die of sickle cell anemia, while those who are heterozygous are resistant to malaria. 5% of the population of the Congo are homozygous recessive for the sickle cell allele. What percentage of the population is resistant to malaria?
The allele for sickle anemia is found at higher frequencies in central Africa than in other parts of the world. What are the advantage and disadvantages?
Why might some light-skinned populations, such as the Japanese, be missing the F374 allele for lighter skin pigmentation?
Explain why the HbS allele is prevalent in certain regions even though it is detrimental in the homozygous condition.
If allele frequencies in the hemoglobin gene are influenced by sickle cell anemia on the one hand and by resistance to malaria on the other hand, what factors may cause a change in these allele frequencies over time?
About 4 percent of people of Northern European descent have a cystic fibrosis allele, but only about 1 in 2,500 of these people actually has the disorder. What is the most likely reason for this finding?