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Explain why acetanilide is less reactive toward electrophilic substitution than aniline.?
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- Explain the reaction for the formation of acetal and hemiacetal. Explain why N,N-disubstituted amide is less acidic than ester. Why only methyl ketone do undergoes haloform reaction. LDA is the base of choice for carbonyl compound to completely convert into enolate. Why?A- What is the definition of acidity? B- Compare the acidity of ammonia and its aliphatic derivatives with of acidity pyrrole C- Melting points of pyrrole is higher than melting point of 1-methyl pyrrole explain your answer D- Why does pyrrole prefer electrophilic substitution reactions? E- Why Pyrrole is considered to be an aromatic compound ? F- Explain the Reimer-Tiemann reaction mechanism of heterocyclic compounds? G- Why pyridine is a weak base? explain your answer? H- Pyridine can react with electrophiles, electrophilic substitution ? explain your answer ? G- Explain the Diels–Alder reaction mechanism of heterocyclic compounds? I- From a-haloketone how can you prepared flowing compounds : Imidazole Oxazole Thiazole J- compared the acidity and basicity of Pyrazole and Imidazole with Pyrrole and Pyridine ?Why is anisole nitrated more rapidly than thioanisole under the same conditions?
- (A)Complete reaction between benzil and sodium borohydride to from benzoin b) complete reaction below between benzil and sodium borohydride to from hydrobenzoinCompare Electrophilic aromatic substitution reactivity to quinoline and isoquinoline. Please, explain with diagrams(−)-Hyoscyamine, an optically active drug used to treat gastrointestinal disorders, is isolated from Atropa belladonna, the deadly nightshade plant, by a basic aqueous extraction procedure. If too much base is used during isolation, optically inactive material is isolated. (a) Explain this result by drawing a stepwise mechanism. (b) Explain why littorine, an isomer isolated from the tailflower plant in Australia, can be obtained optically pure regardless of the amount of base used during isolation.
- Compare isoquinoline and quinoline..Explain their basicity.Which of them will be more susceptible to nucleophilic attack and electrophilic attack ? Explain the reason?Compare the acidity of ammonia and its aliphatic derivatives with of acidity pyrrole?Look at the imide, the nitrogen analog of an anhydride below: a) For a neutral imide, will the carbonyl carbon be more (easier to attack) orless (harder to attack) electrophilic than the C of a neutral anhydride? b) If the imide is hydrolyzed under acidic conditions, which atom, one of theoxygens or the nitrogen, will be protonated? Explain your answer.
- why sulfanilamide is less acidic than sulfathiazole (B), whereas sulfanilylsulfanilamide is more acidic than sulfathiazole? does it relate to hard and soft nucleophiles?Both pyridine and pyrrole are nitrogen containing aromatic heterocyclic compounds. When treated with HCl, only pyridine forms the hydrochloride salt, where as pyrrole is unreactive. What is the best explanation for this observed reactivity.Explain why benzaldehyde is less reactive than cyclohexanecarbaldehyde toward nucleophilic attack.