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- Why anesthesiologist often prefer combined uses of GA instead of single agent?Explain the term first-pass eject or hepatic metabolism of the drug. What effect does first-pass have on drug bioavailability and activity?The plasma concentration of a drug is 50 mg/L and is decreasing in first-order fashion with a half-life of 12 hours. Approximately how may hours will it take for the blood concentration to fall to a desired range of 10-15 mg/L? (A) 12 (B) 24 (C) 36 (D) 48 (E) 50
- Please Write the drug interaction between Atenolol and Clonidine ? Please shortly. Answer should include the effects and mechanism?What is MDI? Briefly Discuss the formulation and drug aerosolization process from a MDI? please discuss at your own words.How does physicochemical properties of a drug define its biological mechanism? Please explain at your own words.
- Briefly explain this statement -"Therapeutic drug monitoring of Warfarin" Please explain at your own words(500-600 words appropriately).Describe the factors that affect both drug absorption and bioavailability.What are the potential implications of genetic variations in drug-metabolizing enzymes on individual response and therapeutic outcomes in clinical pharmacology?
- Discuss three types of drug-drug interactions, and explain the links to pharmacodynamics and/or pharmacokinetics, with examples. Give the mechanims.For each of the following pharmacologic classification of antihypertensive agents, list (a) at least three (3) molecules as examples with (b) corresponding Brand/ Proprietary Names, and (c) two (2) adverse effects (avoid repetition):Identify the binding interactions that might be possible for the drug reported below. Rank these interactions by increasing energy.