F1 mice targeted using CRISPR/Cas9 and an HDR DNA fragment is the first choice when modeling a. Autosomal dominant disorders due to missense mutations b. Autosomal recessive disorders due to knockout mutations C. Autosomal dominant disorders due to haploinsufficiency d. X-linked recessive disorders in females e. Autosomal recessive disorders due to missense mutations

F1 mice targeted using CRISPR/Cas9 and an HDR DNA fragment is the first choice when modeling a. Autosomal dominant disorders due to missense mutations b. Autosomal recessive disorders due to knockout mutations C. Autosomal dominant disorders due to haploinsufficiency d. X-linked recessive disorders in females e. Autosomal recessive disorders due to missense mutations

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter11: Genome Alterations: Mutation And Epigenetics

Section: Chapter Questions

Problem 7QP

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Please Answer with reason: When counseling parents about genetic transmission of an X-linked disorder, which concept does the nurse keep in mind? a. An X-linked disorder can be traced through the paternal lineage. b. A female can only pass an X-liked disorder to a son c. A male can pass an X-linked mutation to a son or a daughter d. A male with a mutation in an X-linked gene will manifest the disease. 5) The nurse explains to parents that if both of them are carriers of an autosomal recessive genetic mutation, the chance of each child NOT inheriting the disease (affected) is a. 25% c. 0% b. 75% d. 50%
Options : Sex XY mutations reversal SRY feminization