Figure 6-33 (Subunit interactions in an allosteric enzyme, and interactions with inhibitors and activators) depicts allosteric modulation of an enzyme through non-covalent interactions. What features of an activator might lead to different levels of enzyme regulation?Select one or more:a.ability to cause a conformational change that results in an altered activity.b.affinity for the regulatory sitec.boiling pointd.bond flexibility (i.e. abundance of freely rotating single bonds instead of more rigid bonds like double bonds)e.molecular weight Chymotrypsinogen(inactive)Trypsinogen(inactive)24516Val-(Asp)4-Lys-Ile-enteropeptidasetrypsin>Val-(Asp)4-LysT-Chymotrypsin(active)Trypsin(active)1 15 162457245Arg IleIleT-chymotrypsin(autolysis)FIGURE 6-33 Activation of zymogens by proteolytic cleavage.Shown here is the formation of chymotrypsin and trypsin from theirzymogens. The bars represent the primary sequences of the polypep-tide chains. Amino acid residues at the termini of the polypeptidefragments generated by cleavage are indicated below the bars. Thenumbering of amino acid residues represents their positions in theSer14-Arg15+ Thr147_Asn148a-Chymotrypsin(active)1 13 16146 149245primary sequence of the zymogens, chymotrypsinogen or trypsino-gen (the amino-terminal residue is number 1). Thus, in the activeLeu IleТyr AlaACforms, some numbered residues are missing. Recall that the threepolypeptide chains (A, B, and C) of chymotrypsin are linked by disul-fide bonds (see Fig. 6–18).

Regulatory enzymes exhibit increased or decreased catalytic activity in response to specific…

Figure 6-33 (Subunit interactions in an allosteric enzyme, and interactions with inhibitors and activators) depicts allosteric modulation of an enzyme through non-covalent interactions. What features of an activator might lead to different levels of enzyme regulation? Select one or more: a. ability to cause a conformational change that results in an altered activity. b. affinity for the regulatory site c. boiling point d. bond flexibility (i.e. abundance of freely rotating single bonds instead of more rigid bonds like double bonds) e. molecular weight

Figure 6-33 (Subunit interactions in an allosteric enzyme, and interactions with inhibitors and activators) depicts allosteric modulation of an enzyme through non-covalent interactions. What features of an activator might lead to different levels of enzyme regulation? Select one or more: a. ability to cause a conformational change that results in an altered activity. b. affinity for the regulatory site c. boiling point d. bond flexibility (i.e. abundance of freely rotating single bonds instead of more rigid bonds like double bonds) e. molecular weight

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter16: The Digestive System

Section: Chapter Questions

Problem 4TAHL

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