FIGURE 9-19 Messenger RNAS produced by alternative splicing of the pre-MRNA of the human FGFR2 gene encode two protein isoforms that bind to different ligands (the growth factors). Alternative splicing produces related but distinct protein isoforms FGFR2 gene 810 7|9| 12 14 1618 11 h3| 15h기 19 Exons! 2 34 %23 Alternative splicing MRNA Ligands: Ligands:, FGF10 FGF7 FGF2 FGF9 FGF4 FGF8 FGF6 Exterior Cell membrane Cytoplasm Fibroblast growth factor receptor 2 First isoform Fibroblast growth factor receptor 2 Second isoform
Nucleotides
It is an organic molecule made up of three basic components- a nitrogenous base, phosphate,and pentose sugar. The nucleotides are important for metabolic reactions andthe formation of DNA (deoxyribonucleic acid) and RNA (ribonucleic acid).
Nucleic Acids
Nucleic acids are essential biomolecules present in prokaryotic and eukaryotic cells and viruses. They carry the genetic information for the synthesis of proteins and cellular replication. The nucleic acids are of two types: deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). The structure of all proteins and ultimately every biomolecule and cellular component is a product of information encoded in the sequence of nucleic acids. Parts of a DNA molecule containing the information needed to synthesize a protein or an RNA are genes. Nucleic acids can store and transmit genetic information from one generation to the next, fundamental to any life form.
Based on Figure 9-19, can you predict the position of a
mutation that would affect the synthesis of one isoform
but not the other?
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