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- Analysis of X-Linked Dominant and Recessive Traits The following is a pedigree for a common genetic trait. Analyze the pedigree to determine whether the trait is inherited as: a. autosomal dominant b. autosomal recessive c. X-linked dominant d. X-linked recessive e. Y-linkedAnalysis of X-Linked Dominant and Recessive Traits Suppose a couple, both phenotypically normal, have two children: one unaffected daughter and one son affected with a genetic disorder. The phenotype ratio is 1:1, making it difficult to determine whether the trait is autosomal or X-linked. With your knowledge of genetics, what are the genotypes of the parents and children in the autosomal case? In the X-linked case?Analysis of X-Linked Dominant and Recessive Traits As a genetic counselor investigating a genetic disorder in a family, you are able to collect a four-generation pedigree that details the inheritance of the disorder in question. Analyze the information in the pedigree to determine whether the trait is inherited as: a. autosomal dominant b. autosomal recessive c. X-linked dominant d. X-linked recessive e. Y-linked
- Analysis of X-Linked Dominant and Recessive Traits In the eighteenth century, a young boy with a skin condition known as ichthyosis hystrix gravior was identified. The phenotype of this disorder includes thickening of skin and the formation of loose spines that are sloughed off periodically. This man married and had six sons, all of whom had the same condition. He also had several daughters, all of whom were unaffected. In all succeeding generations, the condition was passed on from father to son. What can you theorize about the location of the gene that causes ichthyosis hystrix gravior?In this part, you will work out on X-linked traits. Remember that males have only one X chromosome and females have two. For X-linked recessive, use the following designations: XA= normal Xa= the trait (a genetic disease or abnormality) For X-linked dominant, use the following designations: XA= the trait (a genetic disease or abnormality) Xa= normal Determine if the pedigrees below can be for a trait that is X-linked recessive. Write the genotype next to the symbol for each person in the pedigree below. A. Is it possible that this pedigree is for an X-linked recessive trait? B. What can you conclude about the children of mothers affected with an X-linked recessive characteristic? C. What can you conclude about the father of an affected female?man who is a dwarf due to achondroplasia and has normal vision marries a color-blind woman of normal height. The man's father was 6 feet tall, and both the woman's parents were of average height. Achondroplasia is autosomal dominant, and red-green color blindness is X-linked recessive. What are the possible genotypes and phenotypes of their children? What are the ratios for each? you must show all work.
- Color-blindness is an X-linked recessive disorder. Under what circumstances will this condition manifest in a child? Top of Form If the child is a male and its mother has the recessive allele If the child is a female and its father has the recessive allele If the child is a female and its mother has the recessive allele If the child is a male and its father has the recessive alleleYou are a genetic counselor. How would you advise a couple who wants to know their chances of having a baby with Duchenne-muscular dystrophy. Hannah is not a carrier, but her husband Barry has a brother, James, who died from the disease. Duchenne-muscular dystrophy is an x-linked condition, the allele responsible is recessive and people who have the disease die in childhood. a)What are Hannah’s and Barry’s chances of having a baby with Duchenne-muscular dystrophy? b)What are the chances of Barry’s sister having a baby with the disease?A woman is color blind (an X-linked, recessive trait). What are the chances that her sons will be color blind? Show a punnet square
- Y-linked Amelogenesis imperfecta (A), a congenital disorder that affects the formation of the teeth enamel making affected individuals at higher risk for dental cavities and related problems. X-linked dominant hypophosphatemia (H), a form of rickets or vitamin D deficiency that affects the bones which causes pain, osteoarthritis, and abnormal shapeabnormal shape. X-linked recessive progressive Duchenne muscular dystrophy (m), a muscular disorder, leading to an irreversible gradual wasting of skeletal muscles. Hannah, the same as her mom, is heterozygous for both X-linked traits. While her dad is suffering from both muscular dystrophy and hypophosphatemia. Hannah's husband, Joey has a mom suffering from musculardystrophy regardless of having normal bone conditions. His dad has been blessed with strong muscles and bones, however, he is suffering from amelogenesis imperfecta. What are the complete genotypes of each person?a. Joey's momb. Joey's dadc. Joeyd. Hannah's mome. Hannah's dad f.…1. Hemophilia is due to a sex-linked gene. It is recessive and found on the X chromosome. A woman who is a carrier for hemophilia marries a normal man. What will be the possible phenotypes of their children? Use a punnet square. 2. A phenotypically normal man, who has a hemophiliac brother, marries a normal woman, who is not a carrier. What is the probability that any of their children will be hemophiliac? Use a punnet square. 3. Color-blindness is an X-linked, recessive trait. If a normal-sighted woman, whose father was color-blind, marries a colorblind man, what is the probability that they will have a son who is color-blind? Use a punnet square. 4. A man and woman, both of normal vision, have: 1) a color-blind son (#1) who has a daughter of normal vision 2) a daughter (#1) of normal vision who has one color-blind son and one normal vision son 3) another daughter (#2) of normal vision who has five sons, all with normal vision What are the probable genotypes of the…Y-linked Inheritance. Holandric genes are inherited by males only. Assuming that a man with hypertrichosis is married to a woman and they had children 1. what is the probability that his sons inherit the trait? 2. what is the probability that his daughters inherit the trait?