[GAINI- is a protein coding gene that regulates cardiomyocyte metabolism in patients with heart failure. Mutations in GAIN1 have been linked to hypertrophic cardiomyopathy, a disease in which the heart muscle becomes thick- or hypertrophied.] (ii) A cardiovascular scientist wishes to study the function of cardiomyocytes from some of the patients who possess interesting mutations in GAIN1 (a made-up protein) but is unable to isolate cells from these individuals-who are unwilling to let the scientist perform surgery for a cardiac biopsy-. The scientist decides to take skin fibroblasts from these individuals and "reprogram" them into cardiomyocytes for use in his studies. -Explain two ways that the scientist could pursue to do this? -How could the scientist test that it worked? -Name one laboratory technique that the scientist could use to test this.

[GAINI- is a protein coding gene that regulates cardiomyocyte metabolism in patients with heart failure. Mutations in GAIN1 have been linked to hypertrophic cardiomyopathy, a disease in which the heart muscle becomes thick- or hypertrophied.] (ii) A cardiovascular scientist wishes to study the function of cardiomyocytes from some of the patients who possess interesting mutations in GAIN1 (a made-up protein) but is unable to isolate cells from these individuals-who are unwilling to let the scientist perform surgery for a cardiac biopsy-. The scientist decides to take skin fibroblasts from these individuals and "reprogram" them into cardiomyocytes for use in his studies. -Explain two ways that the scientist could pursue to do this? -How could the scientist test that it worked? -Name one laboratory technique that the scientist could use to test this.

Name: B7 [GAIN1 – is a protein coding gene that regulates cardiomyocyte meta
Uploaded: 2024-03-20T06:42:55.000Z
Channel: Bartleby
Description: B7 [GAIN1 – is a protein coding gene that regulates cardiomyocyte metabolism in patients with heart failure.Mutations in GAINI have been linked to hypertrophic cardiomyopathy, a discase in which the heartmuscle becomes thick - or hypertrophied.](ii)

Basic Clinical Laboratory Techniques 6E

6th Edition

ISBN:9781133893943

Author:ESTRIDGE

Publisher:ESTRIDGE

Chapter7: Basic Clinical Microbiology

Section7.5: Tests For Group A Streptococcus

Problem 4RQ

See similar textbooks

Similar questions

31 A research student is investigating artificial substitutes for human blood inemergency blood loss situations. For example, a person has suffered a traumaresulting in a large open wound and has lost a large volume of blood. The wound hasbeen temporarily closed and blood loss has been slowed.Consider the above scenario to answer the following questions in sentence format.a. While blood supports many functions, what would be the primary short-termpurpose of artificial blood in this scenario?b. What characteristics would artificial blood need to have in order to functionwell in the body to address acute blood loss?c. What type of tissue is blood?
What features of the bypass polymerase make it ideal for its role in translesion synthesis, shown in Figure 16-24?
Do you think platelets can synthesize proteins?Why or why not?
Why is angiogenesis important to cancer development?
how does covid 19 affects cardivascular system of the body and how does cardic complections can reduce life expectancy and an impact on your day to day living ?
Proteins found in the blood respond to blood vessel damage by clumping together forming a clot that physically blocks the hole in the vessel and prevents further blood loss. If clotting proteins were active all the time, they would create clots throughout your circulatory system. Which of the following would be the most efficient way for the body to regulate the expression of the proteins involved in clotting? A. Tightly package the genes for clotting proteins so that RNA polymerase cannot access them unless they are needed. B. Produce and store the clotting protein in an inactive form. When the protein is needed, use another protein to activate the clotting protein. C. Constantly make the clotting proteins, but then break them down instantly after translation if they are not needed. D. Use a repressor protein to keep clotting genes turned off until they are needed.
What is angiogenesis, and why do mutations that effect angiogenesis affect tumor development?
Streptokinase is asubstance used in thetreatment of acute myocardialinfarction. How does thissubstance act?
Why is the gap junctions between heart muscle cells play a relevant role in producing a regular heartbeat?
Do the Fibrin form the bridges between aggregating platelets? How?
Why are the activated platelets essential in the process of clotting?
One of the more common adverse effects of cancerchemotherapy is the destruction of leukocytes. Before hisnext scheduled chemotherapy treatment, a patientundergoes a blood test called an absolute neutrophil count(ANC), which reveals that his neutrophil count is 1900 cells per microliter. Would his healthcare team be likely toproceed with his chemotherapy treatment? Why?