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Neuropathy is often a side effect of anti-cancer drug treatments. Which of the following drugs induce neuropathy by disrupting microtubule formation thereby inhibiting axonal transport? Select ALL that apply
Paclitaxel
Oxaliplatin
Vincristine
Bortezomib
Thalidomide
Cisplatin
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Solved in 2 steps
- Which of the following classes of oncogenes would likely be druggable with a small molecule (select all that apply)? A. Nuclear hormone receptor B. RAS C. Serine/Threoine Kinase D. Transcription Factor E. Receptor Tyrosine KinaseA pharmaceutical company just developed a drug (Cytarabine) that inhibits the activity of cytosine deaminase but increases intracellular concentrations of ara-dCTP in tumor cell. This will likely produced increased tumor sensitivity to Cytarabine. Group of answer choices True FalseWhich of the following describes a mechanism by which microtubules are known to be stabilized? Conformational changes undertaken by beta-tubulin as it hydrolyzes GTP. Binding of microtubule binding proteins, such as Tau. Shortening of the GTP cap. Increasing the proportion of alpha-tubulin subunits relative to beta-tubulin subunits.
- Heterotypic interactions of tumor cells have been a fertile area for potential therapeutic interventions. Find a specific example of a drug/therapy that targets these interactions and explain the mechanism by which it treats cancer.Proteins/peptides exclusively expressed by tumor cells are termed as a. tumor associated antigens B. tumor specific antigens Chemotherapy or radiation therapy targets cancer cells more than normal cells because cancer cells express different or mutated proteins on their cell surface Tumors of cancer cells have more blood vessels than normal tissues The therapies enhance antitumor immune response Cancer cells proliferate much faster than normal cellsChemotherapeutic agents can promote apoptosis in cancer cells by these mechanisms except; Group of answer choices Downregulating MCL1 expression Increasing BCL-2 expression Increased p53 expression Increased BIM (BH-3) expression
- If a drug interferes with the formation of microtubules , its effectiveness must be related to disruption of mitotic spindle formation suppression of cyclin production inhibition of DNA synthesis myosin denaturation and inhibition of cleavage formationIn a cancer research lab,normal cells have specific biomarker AAP1 while cancer cell display SSR1 biomarker. Which cell biology technique will help you to know the number of cancerous cells as compared to normal cell using this biomarkers?Give details experimental and logical explanation.Some cancers are detectable with a simple blood test (if the cancer cells secrete a chemical that circulates in the blood). A spherical tumor 3 cm in diameter may result in a concentration in the blood of 20 nanograms/milliliter of the chemical to be detected. The most common type of blood test can only detect the presence of this chemical in the blood if the concentration is greater than about 0.1 ng/ml. Another way to check is with an MRI scan, which can detect a tumor down to about a diameter of 1 mm. Which test is more sensitive? (Hint: this is a scaling prolem. Determine the size of a tumor that would produce a blood concentration of just under 0.1 ng/ml, which is undetectable by a blood test. Would an MRI be able to detect it?). Answer: In scaling problems, we need a linear scale factor. 0.1 ng/ml is 200 times smaller than 20 ng/ml, and we want to know what diameter of tumor will produce that amount. Assuming the secretion is based on the volume of the tumor, then we have λ 3 =…
- Figure 9.8 HER2 is a receptor tyrosine kinase. In 30 percent of human breast cancers, HER2 is permanently activated, resulting in unregulated cell division. Lapatinib, a drug used to treat breast cancer, inhibits HER2 receptor tyrosine kinase autophosphorylation (the process by which the receptor adds phosphates onto itself), thus reducing tumor growth by 50 percent. Besides autophosphorylation, which of the following steps would be inhibited by Lapatinib? Signaling molecule binding, dimerization, and the downstream cellular response. Dimerization, and the downstream cellular response. The downstream cellular response. Phosphatase activity, dimerization, and the downsteam cellular response.The most common therapeutic approaches to treating cancer include all of the following except ________. a. chemotherapy b. irradiation of tumors c. surgery to remove cancerous tissue d. administering doses of vitaminsSome cancer cells are insensitive to typical chemotherapy. Research into the mechanisms underlying this insensitivity uncovered an ability by these cells to pump the treatment drug out of the cell against its concentration gradient. Additional drugs have been developed that inhibit the pump, thus trapping the chemotherapeutic agent inside to promote cancer cell destruction. The Figure shows what happens when two types of cells are treated with a 3H-labeled anti-cancer drug, paclitaxel. Two additional drugs, imatinib and nilotinib, are evaluated for their ability to overcome the cancer cells ability to pump out the chemotherapeutic agent. An asterisk (*) indicates a statistically significant difference from the cells receiving paclitaxel alone. Do the additional drugs seem to the effective in over-coming the pump? Which set of graphs (A or B) best supports your answer? Explain your answer.
