Gene X is expressed in the developing brain, heart, andlungs of mice. Mutations that selectively affect gene Xfunction in these three tissues map to three differentregions (A, B, and C, respectively) 5′ of the X codingregion.a. Explain the nature of these mutations.b. Draw a map of the X locus consistent with the preceding information.c. How would you test the function of the A, B, and Cregions?

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Gene X is expressed in the developing brain, heart, and
lungs of mice. Mutations that selectively affect gene X
function in these three tissues map to three different
regions (A, B, and C, respectively) 5′ of the X coding
region.
a. Explain the nature of these mutations.
b. Draw a map of the X locus consistent with the preceding information.
c. How would you test the function of the A, B, and C
regions?

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