Genetics Constrict a Table: (i) Compare and contrast the down syndrome, pattau syndrome, turnor syndrome, Klinefelter syndrome, trisomy 21, trisomy 18. (ii) compare and contrast the different inheritance disorders in pedigree. (iii) compare and contrast the mendalin and non- mendalin types in detail (with all types). Thanks in advance.
Q: 3.9 Which mode of inheritance is suggested by the fol- lowing pedigree? Based on this hypothesis,…
A: Pedigree is a diagrammatic representation of either phenotypes or genotypes of a particular organism…
Q: Explain why in human families, many traits (albinism, phenylketonuria, blue eyes ) skip a generation…
A: Introduction :- Phenylketonuria, or PKU, is a rare hereditary condition in which the amino acid…
Q: As discussed in the text, almost 5% of Caucasians carry a recessive gene for cystic fibrosis. Until…
A: Cystic fibrosis is an inherited disease which is characterized by formation of thick, sticky mucus…
Q: The pedigree to the right shows a pattern of inheritance for galactosemia, a rare autosomal…
A: The pedigree to the right shows a pattern of inheritance for galactosemia, a rare autosomal…
Q: What is a genetic interval?
A: The functional unit of heredity is known as genes. They consist of deoxyribonucleic acids(DNA). Some…
Q: Duchenne’s muscular dystrophy (DMD) is a devastating X-linked recessive disease that causes muscle…
A: DMD is a fatal neuromuscular disorder caused by a recessive mutation on the X chromosome. The…
Q: hair, underdeveloped nails, and abnormally shaped eyelids. In the following pedigree, which…
A:
Q: In the 1800s, a man with dwarfism who lived in Utah produced a large number of descendants: 22…
A: Step 1: SMCD or Schmid metaphyseal chondrodysplasia refers to the progressive short hight that…
Q: Working with the definitions of penetrance and expressivity, analyze the following pedigree and…
A: Penetrance measures the degree of any disease gene expressed in the genotype of the individual.…
Q: Many genetic disorders exhibit locus heterogeneity. Define andgive two examples of locus…
A: Locus heterogeneity is a phenomenon in which a particular disease is caused by mutations in…
Q: Do you think mendal's law of inheritence would have been different if the character that he choose…
A: Gregor Mendel was a scientist who worked in the field of molecular biology and genetics. These…
Q: Which are the two kinds of biological abnormalities that could conceivably be inherited ?
A: Biological abnormalities refer to any condition of the body that alters from the normal parameter;…
Q: The following pedigree illustrates the inheritance of ringed hair, a condition in which each hair is…
A: The condition in which a single dominant allele is responsible for causing the disease then the…
Q: that follows Mendelian rules of inheritance, what is the only way an organism can have the recessive…
A: Mendel explained his results by describing two laws of inheritance that introduced the idea of…
Q: Two average sized parents have three children. The first child is very short, the second child is…
A: Hi, Thanks For Your Question. Answer : Height Is Determined By A Number Of Genes, Each Of Which…
Q: xamine the pedigree. If individual I-1 is a carrier for the Robertsonian translocation leading to…
A: Down syndrome is characterised by a combination of phenotypic features that include mental…
Q: Ectrodactyly is a rare condition in which the fingers are absent and the hand is split. This…
A: Ectrodactyly is a genetic disorder which is usually inherited as an autosomal dominant trait. The…
Q: The pedigree below tracks the inheritance of a genetic disorder through a family's generation. I II…
A: This given pedigree has three generations (I, II, III) and nine individuals. Among them, five…
Q: Which of the following disorders in humans has an X-linked recessive inheritance pattern?…
A: X-linked recessive inheritance refers to genetic conditions associated with mutations in genes on…
Q: How does the Chromosomal Theory of Inheritance helped to advance our understanding of genetics?
A: The Chromosomal Theory of Inheritance was founded in 1902 by Theodor Boveri and Walter Sutton. This…
Q: a. Draw the pedigree of this family. Follow protocols in making a pedigree. MALE b. What is the mode…
A: Genetics is the study of genes, their interactions, and the effect of environment on genes. Broadly…
Q: What is a pedigree?
A: An organism is a living thing. It has an organized structure, and it can grow, react to stimuli,…
Q: *22. Dent disease is a rare disorder of the kidney in which reabsorption of filtered solutes is…
A: DNA is the genetic material in most living organisms. DNA contains inheritable segments that are…
Q: three children. What is the probability that one their children will be normal (unaffected) and two…
A: Autosomal recessive mutation leads to autosomal recessive disorder. This will occur when you…
Q: Albinism in humans is inherited as a simple recessive trait. For the Following families, determine…
A: Albinism is a autosomal trait.
Q: Holstein dairy cows normally have black-and-white coats. Sometimes, calves with a recessive…
A: "Inheritance" is the process through which a child gets genetic information from his or her parents.…
Q: Working with the definitions of penetrance and expressivity, analyze the following pedigree and…
A: Sex linked disease The disease which are caused by mutation in the sex chromosomes is known as sex…
Q: a. On the basis of this pedigree, what do you think is the most likely mode of inheritance for…
A: Humans carry 23 pair of chromosome - 22 pairs of autosomes and a pair of sex chromosomes. Sex…
Q: Let’s suppose you have pedigree data from thousands of differentfamilies involving a particular…
A: Gene is a functional unit of heredity. A gene is a sequence of nucleotides in genome that codes for…
Q: This pedigree traces the inheritance of a rare disease in humans. a. Based on this pedigree, is the…
A: Answer is given below.
Q: What are twins? Genetically, what are the two types of twins that can occur?
A: Introduction In this question we have to define twins and have to discuss about the types of twins,…
Q: Q1: Which two children in this pedigree have cystic fibrosis? How do you know? Q2: Does either parent…
A: Cystic fibrosis is an autosomal recessive disorder.
Q: With regard to pedigree analysis, make a list of observations thatdistinguish recessive, dominant,…
A: Pedigree analysis is a diagrammatic representation used to determine the mode of inheritance of…
Q: Each of us is genetically unique. Describe two processes that ensure that your future full sibling…
A: DNA is the genetic material present in most of the living organisms. The DNA is made up of 4…
Q: mammals, albinism is caused by an autosomal allele that interferes with skin pigment. Early one…
A: Albinism is an autosomal recessive trait. Normal = AA, Aa Albino = aa
Q: Are Mendel’s principles of segregation and independent assortment even relevant today in the age of…
A: DNA is the genetic material in most living organisms. It is the information hub of the cell that…
Q: The pedigree below shows inheritance of a particular autosomal trait across three generations. Males…
A: Pedigree is a family tree that is made up of symbols and line. Pedigree represents person’s family…
Q: Ectrodactyly is a rare condition in which the fingers are absent and the hand is split. This…
A: A pedigree chart is a family tree that depicts the genetic representation of inheritance of a…
Q: The pedigree pictured is of an extended family where a large percentage of family members develop…
A: Colon cancer , a form of cancer which starts in the large intestine and spreads throughout the body…
Q: Explain, at the molecular level, why human genetic diseases oftenfollow a simple Mendelian pattern…
A: Genes are the set of nucleotides present in a chromosome that encodes for particular information…
Q: The pedigree below shows the inheritance of fur color in rabbits. What is the mode of inheritance…
A: Pedigree analysis is a chart which shows the complete record of inheritance of certain genetic…
Q: Marfan syndrome is a rare inherited human disorder characterizedby unusually long limbs and digits…
A: Marfan syndrome is a genetic disorder of connective tissues. In this, the connective tissues present…
Q: The accompanying pedigree shows a family in which one child (II-1) has an autosomal recessive…
A:
Q: The following pedigree illustrates the inheritance of a rare neurologicaldisease. What is the most…
A: Inheritance is the process by which this genetic information present in the genes is passed on from…
Q: 2. 3 7. II 2. 7. 8. (i) Predict the mode of inheritance of the genetic disorder. Explain. (ii) Which…
A: Pedigree is a family chart showing the inheritance of a particular trait through several generations…
Q: Define about Tay–Sachs Disease:The Molecular Basis of a Recessive Disorder in Humans ?
A: To produce disease, both genes in a pair must be faulty. Carriers are people who have only one…
Q: Pedigree A: YES or NO Could this trait be inherited as a simple autosomal recessive? Could this…
A:
Q: The following pedigree illustrates the inheritance of ringed hair, a condition in which each hair is…
A: The process in which the qualities or genetic characters transmit from parent to their progeny is…
Genetics
Constrict a Table:
(i) Compare and contrast the down syndrome, pattau syndrome, turnor syndrome, Klinefelter syndrome, trisomy 21, trisomy 18.
(ii) compare and contrast the different inheritance disorders in pedigree.
(iii) compare and contrast the mendalin and non- mendalin types in detail (with all types).
Thanks in advance.
Step by step
Solved in 4 steps with 2 images
- Working with the definitions of penetrance and expressivity, analyze the following pedigree and assume that the father of the proband is homozygous for a rare trait. (Consider a rare trait here to be less than 1 in 30,000.) What pattern of inheritance other than autosomal recessive could explain this pedigree? In particular, explain the genotype and phenotype of the proband (arrow).Individuals affected by a condition known as polydactyly have extra fingers or toes. The following pedigree shows the pattern of inheritance of this trait in one family: From the pedigree, can you tell if polydactyly comes from a dominant or recessive allele? Is the trait sex-linked? As far as you can determine, what is the genotype of each person in the pedigree with respect to the trait?Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you decide to have a child if the test results said that you carry the mutation for breast and ovarian cancer? The heart disease mutation? The TSD mutation? The heart disease and the mutant alleles?
- Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you want to know the results of the cancer, heart disease, and TSD tests if you were Sarah and Adam? Is it their responsibility as potential parents to gather this type of information before they decide to have a child?Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. If Sarah carries the mutant cancer allele and Adam carries the mutant heart disease allele, what is the chance that they would have a child who is free of both diseases? Are these good odds?211 Inheritance 2. The pedigree chart below illustrates the inheritance of a trait (darker symbols) in two families joined in marriage. 2 4 6 8. 10 11 12 13 14 II 4 5 (a) State whether the trait is dominant or recessive, providing a reason for your choice: (b) State whether the trait is sex-linked or not, providing a reason for your choice: 3. The recessive sex-linked gene (h) prolongs the blood-clotting time, resulting in the genetically inherited disease called hemophilia. From the information in the pedigree chart (right), answer the following questions: Hemophilia in humans (a) If 112 marries a normal man, what is the probability of her first child being a hemophiliac? 1 (b) Suppose her first child is actually a hemophiliac. What is the chance that her second child will be a boy with hemophilia? 4 (c) If 114 has children with a hemophiliac man, what is the probability that her first child will be phenotypically normal? (d) If the mother of 12 was phenotypically normal, what…
- QUANTITATIVE Recall that hemophilia is an X-linked recessive disease. If a woman with hemophilia had children with a man without hemophilia, what is the chance that their first child will have the disease? What is the chance that their first child will be a carrier?The pedigree pictured is of an extended family where a large percentage of family members develop colon cancer at an early age. In this family, individuals either get colon cancer before the age of 16, or they don’t get it at all. a) Based on the information you have been given, what evidence, if any, suggests an inherited contribution to the development of this disease? b) You take a medical history of all 33 people in the pedigree and discover that a large percentage drink a special coffee on a daily basis, while others do not. The individuals who do not drink coffee are I-1, II-2, II-4, II-9, III-7, III-13, IV-1, and IV-3. Could drinking this special coffee play a role in colon cancer? Explain.A study of three generations in a family of a male colleague of the authors indicated that many of the man's blood relatives had died of cardiovascular accidents and coronary heart disease. Others died of other causes but were affected by high blood pressure. What are the implications of this information for the man in question? b. What information and help might a genetic counselor provide?
- As a genetic counselor, you may face some ethical dilemmas.Imagine that a couple came to your office to discuss potential color blindness in their children.The man is not color blind, but his wife is. They already have one daughter that is color blindand want to know the probability of future children having the disorder. First, you will need toexplain to the couple the difference between sex chromosomes and autosomal chromosomes andthat color blindness is caused by a recessive mutation in a gene found on the X chromosome.Once they understand this, you can then explain to them the probability of other offspring havingthe disorder. What is the dilemma in this case and why might you need to suggest to the couplethat they see a marriage counselorIn mice, dwarfism is caused by an X-linked recessive allele, and pink coat is caused by an autosomal dominantallele (coats are normally brownish). If a dwarf femalefrom a pure line is crossed with a pink male from a pureline, what will be the phenotypic ratios in the F1 and F2 ineach sex? (Invent and define your own gene symbols.)Albinism is inherited as a recessive trait in humans. If the parents are both heterozygous for the trait, what is the probability of obtaining the following: a. 3 albino children? b. 2 normal girls? c. 4 albino boys? d. first 4 children will be normal and the last 2 children will be albino? e. 4 normal children and 2 albinos in any order?