Gly-Pro-Glu (Glypromate) is a neuroprotective compound originally developed at the University Auckland. After showing promise for the treatment of neurodegenerative diseases such as Huntington's, Parkinson's and Alzheimer's diseases the compound was passed to Neuren Pharmaceuticals who began development of the drug in collaboration with Pfizer. Glypromate Design a solid-phase synthesis of the tripeptide Gly-Pro-Glu, using Fmoc-protected amino acids. Ensure to include all synthetic steps (resin loading, protection, coupling, deprotection) and sugges

Gly-Pro-Glu (Glypromate) is a neuroprotective compound originally developed at the University Auckland. After showing promise for the treatment of neurodegenerative diseases such as Huntington's, Parkinson's and Alzheimer's diseases the compound was passed to Neuren Pharmaceuticals who began development of the drug in collaboration with Pfizer. Glypromate Design a solid-phase synthesis of the tripeptide Gly-Pro-Glu, using Fmoc-protected amino acids. Ensure to include all synthetic steps (resin loading, protection, coupling, deprotection) and sugges

Introduction to General, Organic and Biochemistry

11th Edition

ISBN:9781285869759

Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Chapter19: Carboxylic Anhydrides, Esters, And Amides

Section: Chapter Questions

Problem 19.6P

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The crocodile, which can remain under water without breathing for up to 1 h, drowns its air-breathing prey and then dines at its leisure. An adaptation that aids the crocodile in doing so it that it can utilize virtually 100% of the O2in its blood whereas humans, for example, can extract only ~65% of the O2in their blood. Crocodile Hb does not bind BPG. However, crocodile deoxyHb preferentially binds HCO3ꟷ. How does this help crocodile obtain its dinner? Explain your answer.
Systematically outline a protocol you will follow to process adulterated palm oil to gain qualitative and quantitative information spectroscopically about any added toxic dye. Explain also the basis for your protocol of choice.
9.A linear polyester was synthesized from a mixture of diacid and glycol with carboxyl to hydroxyl ratio greater than unity. A sample of the polyester (3.5 g) requires titration with 23 mL of N/50 KOH to reach a phenolphthalein end point. By vapor-pressure osmometry the molecular weight of the polymer was determined to be 12,000. Calculate the average carboxyl functionality of the polymer (that is, average number of carboxyl groups per polymer molecule).
Hexanoic acid was added to an immiscible biphasic solvent sysem, water and CCl4 at 20.0OC and the equilibrium concentrations of hexanoic acid were determined to be 3.66 g/L in H2O and 67.0 g/L in CCl4. Caluclate the distrubution coeffiecent (D1) of hexanoic acid in CCl4 with respect to water.
What are the nonprotein nitrogen components of the blood. Give their chemical structures and relative physiologic concentrations and describe their biosynthesis and excretion. Kindy insert your references. Thank you!
You are employed as a coop student at the Drug and Alcohol Testing Association of Canada (DATAC) developing analytical tests for sports doping agents. You are asked to prepare a procedure for the extraction of methylphenidate, the active compound in Ritalin, from urine samples (consider them as simple aqueous layers, you do not need to consider other components!). The goal of the procedure is to extract the methylphenidate into an organic layer which will then be evaporated, and the residue will be tested for the drug.You find that methylphenidate is highly soluble in 2-methyltetrahydrofuran, a bio-renewable solvent. Draw the structure of 2-methyltetrahydrofuran and give two reasons why it is a good solvent choice for liquid-liquid extraction.
You are employed as a coop student at the Drug and Alcohol Testing Association of Canada (DATAC) developing analytical tests for sports doping agents. You are asked to prepare a procedure for the extraction of methylphenidate, the active compound in Ritalin, from urine samples (consider them as simple aqueous layers, you do not need to consider other components!). The goal of the procedure is to extract the methylphenidate into an organic layer which will then be evaporated, and the residue will be tested for the drug.Your colleague is helping you develop the urine test. They suggest that the urine should be adjusted to a pH above 7 before extracting with the organic solvent. Why is this necessary? Support your explanation with a full arrow-pushing mechanism for the reaction that would occur if the pH was below 7. Include all formal charges, intermediates (if applicable) and products.
Phenol reacts with three equivalents of bromine in CCl4 (in the dark) to give a product of formula C6H3OBr3. When thisproduct is added to bromine water, a yellow solid of molecular formula C6H2OBr4 precipitates out of the solution. The IRspectrum of the yellow precipitate shows a strong absorption (much like that of a quinone) around 1680 cm-1. Proposestructures for the two products
It has been noticed that adulteration of palm oil with carcinogenic dyes are on the rise. Use your knowledge in analytical processes to systematically process adultrated palm oil to gain qualitative and quantitative information spectroscopically about any added toxic.Explain also the basis for your protocol of choice
On a paper, draw a schematic diagram on the Extraction of Saponins from Gugo by Lead Method using the procedures stated below. Procedures (Stas-Otto Method): Extraction of Saponins from the Gugo Bark by Lead Method Extract saponins from gugo by boiling about 10g of small pieces of gugo bark in water. (If necessary, extract first with ether or petroleum ether). Filter and add a neutral lead acetate solution to the aqueous solution; acid saponins, if present, are precipitated as lead salts. To the filtrate (including the washings, concentrated by evaporation), add basic lead acetate to precipitate neutral saponins. Wash the lead precipitate and suspend in water. Decompose by passing H2S Filter PbS and absorbed impurities. Concentrate the filtrate and finally allow to evaporate to dryness or in vacuum over H2SO4. Purify the saponins by CHCl3 and precipitate with ether. Weigh the residue and compute the percentage yield.
it has been noticed that adulteration of palm oil with carcinogenic dyes are on the rise. Use your knowledge in analytical processes to systematically outline a protocol you will follow to process adulterated palm oil to gain qualitative and quantitative information spectroscopically about any added toxic dye. Explain also the basis for your protocol of choice.
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