Glycogen that is broken down in the muscle is not released as glucose into the circulation because the muscle lacks... Group of answer choices glucose-6-phosphatase phosphoryalse glycogen synthase hexokinase
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- what is one physiological consequence that might occur if gluconeogenesis was the exact opposite of glycolysis? please helpGlycogen synthase may be regulated by covalent modification and/or allosteric control. Label the diagram with the appropriate terms to describe glycogen synthase regulation. Use the following options: Glucose-6-Phospate; Insulin; Fructose-2,6-Bisphosphate; Phosphorylation, DephosphorylationIn order for a fatty acid stored in an adipocyte to be oxidized by a muscle cell, which of the following will need to be present/utilized? Check all that apply. Multiple answers can be selected Acyl CoA Synthetase CD36 malate-aspartate shuttle dephosphorylated hormone-sensitive lipase GLUT 4
- CHOOSE THE CORRECT LETTER When glycogen is synthesized in both the liver and muscle, all the following are true, EXCEPT A.Glucose is transferred from UDP-glucose to a growing glycogen molecule by glycogen synthase.B. Phosphoglucomutase converts glucose 6-phosphate to glucose 1-phosphateC. Glucose 6-phosphate is converted to glucose by a phosphatase.D.Glucose 1-phosphate is activated by UDP-glucose pyrophosphorylase to produce UDP-glucose and PPi.A higher concentration of NADH in the liver is associated with an increase in gluconeogenesis. Your thoughts on this assertion?Please answer the following question: Answer the following questions about Glygogen Metabolism: (But DON’T Just think about glycogen here!) a. After a carbohydrate-filled breakfast, your blood glucose levels increase. How does glucose affect liver glycogen phosphorylase activity? Briefly explain the direct effect (i.e., not via hormones) glucose has on the enzyme, referring to the structure of the enzyme. b. Imagine you develop a drug that targets glycogen synthase kinase as a treatment for Type 2 diabetes. You need to determine if this drug activates or inhibits glycogen synthase kinase? What effect should the drug have on the phosphorylation state and activity of glycogen synthase? Explain in detail your decision. c. Would protein phosphatase 1 (PP1) have to be active or inactive for this drug to be effective? Explain the rationale for your response; be sure to refer to the function of PP1 in your response.
- Patients with von Gierke’s disease (a glycogen storage disease) lack glucose-6- phosphatase activity. Two prominent symptoms of this disorder are fasting hypoglycemia and lactic acidosis. Can you explain why these symptoms occur?DEFINE THE FOLLOWING TERMS: a) Gluconeogenesis b) Glycolysis c) Citric Acid Cycle Please explain this in-detailed and longer, thank you.Which of these enzymes is needed to maintain a steady pool of methylene THF used in pyrimidine synthesis and cancer cells proliferation? Group of answer choices Phosphoglyceratedehydrogenase Glyceraldehydegehydrogenase Glycine decarboxylase Thymidylatesynthase
- Explain what biochemical pathway/metabolic processes are affected in insulin resistance? How does this affect glycogen breakdown and gluconeogenesis.Can you please pick the right answer in each parentheses? Gluconeogenesis is essentially ["a bypass of glycolysis", "the reverse of glycolysis"] , providing a way of counteracting low levels of ["glucose", "ATP"] . There are 10 enzyme catalyzed steps in glycolysis and gluconeogenesis employs ["seven of them", "none of them"] . ["pyruvate carboxylase", "pyruvate kinase"] is a key enzyme in gluconeogenesis, serving to take pyruvate to ["oxaloacetate", "phosphoenolpyruvate"].Which of these enzymes/complexes will insulin activate in the liver? Choose all that apply. Glycogen synthase Glycogen phosphorylase Acetyl-CoA carboxylase Carnitine shuttle PFK-1 FBPase-1