6 Based on the EC50 values for the compounds below, explain why rigid analogs may notalways be more potent or efficacious than the more flexible analog.H HRR"H,HEC50 = 100 nMEC50 = 10 nMEC50 = 1000 nM

Answered: Image /qna-images/answer/8d100ac7-98cc-479e-b6de-6bc764cc4f92.jpg

Answered: H H .R .R C50 = 100 nM EC50 = 10 nM…

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H H .R .R C50 = 100 nM EC50 = 10 nM EC50 = 1000 nM %3D

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter14: Mass Spectrometry

Section: Chapter Questions

Problem 14.37P

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Question

Based on the EC50 values for the compounds below, explain why rigid analogs may not
always be more potent or efficacious than the more flexible analog.
H H
R
R
"H,
H
EC50 = 100 nM
EC50 = 10 nM
EC50 = 1000 nM

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