Here is a family pedigree for an imprinting disorder caused by a loss of function mutation in a single imprinted gene. After generation I only related individuals are shown. You can assume that the parents not included in the pedigree did not carry the mutation. %3D II IV V Male Female Affected Carrier a) Does the mutation involve a gene that is normally expressed from the maternal or from the paternal allele? Briefly explain your logic. b) Identify two ways in which the pattern of inheritance shown in the pedigree is different from X-linked inheritance Parthenogenesis has been documented in most vertebrate Classes (e.g. birds, fish) but never in mammals. Genomic imprinting provides one explanation for this observation. Why? I.

Here is a family pedigree for an imprinting disorder caused by a loss of function mutation in a single imprinted gene. After generation I only related individuals are shown. You can assume that the parents not included in the pedigree did not carry the mutation. %3D II IV V Male Female Affected Carrier a) Does the mutation involve a gene that is normally expressed from the maternal or from the paternal allele? Briefly explain your logic. b) Identify two ways in which the pattern of inheritance shown in the pedigree is different from X-linked inheritance Parthenogenesis has been documented in most vertebrate Classes (e.g. birds, fish) but never in mammals. Genomic imprinting provides one explanation for this observation. Why? I.

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Description: Here is a family pedigree for an imprinting disorder caused by a loss of functionmutation in a single imprinted gene. After generation I only related individuals areshown. You can assume that the parents not included in the pedigree did notcarry the

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter11: Genome Alterations: Mutation And Epigenetics

Section: Chapter Questions

Problem 16QP: Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior...

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Duchenne muscular dystrophy is a recessive disorder caused by a rare,loss-of-function allele that is located on the X chromosome in humans. Anunaffected woman (i.e., without disease symptoms) who is heterozygousfor the X-linked allele causing Duchenne muscular dystrophy has childrenwith a man with a functional (non-disease-causing) allele. What is theprobability that this couple will have an unaffected son?
In Drosophila, a cross (cross 1) was made between twomutant flies, one homozygous for the recessive mutationbent wing (b) and the other homozygous for the recessivemutation eyeless (e). The mutations e and b are alleles oftwo different genes that are known to be very closelylinked on the tiny autosomal chromosome 4. All the progeny had a wild-type phenotype. One of the female progeny was crossed with a male of genotype b e/b e ; we willcall this cross 2. Most of the progeny of cross 2 were of theexpected types, but there was also one rare female ofwild-type phenotype.a. Explain what the common progeny are expected tobe from cross 2.b. Could the rare wild-type female have arisen by (1)crossing over or (2) nondisjunction? Explain.
Genes that cause Prader-Willi syndrome and Angelman syndromeare closely linked along chromosome 15. Although people withthese syndromes do not usually reproduce, let’s suppose that acouple produces two children with Angelman syndrome. The oldestchild (named Pat) grows up and has two children with Prader-Willi syndrome. The second child (named Robin) grows up andhas one child with Angelman syndrome.A. Are Pat and Robin’s parents both phenotypically normal ordoes one of them have Angelman or Prader-Willi syndrome? Ifone of them has a disorder, state whether it is the mother or thefather, and explain how you know.B. What are the sexes of Pat and Robin?
Genes that cause Prader-Willi syndrome and Angelman syndromeare closely linked along chromosome 15. Although people withthese syndromes do not usually reproduce, let’s suppose that acouple produces two children with Angelman syndrome. The oldest child (named Pat) grows up and has two children with PraderWilli syndrome. The second child (named Robin) grows up andhas one child with Angelman syndrome.A. Are Pat and Robin’s parents both phenotypically normal ordoes one of them have Angelman or Prader-Willi syndrome? Ifone of them has a disorder, state whether it is the mother or thefather, and explain how you know.B. What are the sexes of Pat and Robin? Explain.
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