High throughput whole genome sequencing, RNA-seq and ChIP-seq have all been made possible by the advent of next generation sequencing (NGS) technology. Explain these technologies and provide examples of how they have been used to better understand gene function and gene regulation.

High throughput whole genome sequencing, RNA-seq and ChIP-seq have all been made possible by the advent of next generation sequencing (NGS) technology. Explain these technologies and provide examples of how they have been used to better understand gene function and gene regulation.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter13: An Introduction To Genetic Technology

Section: Chapter Questions

Problem 23QP

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Concept explainers

Genomic studies

Genomic studies (genomics) is the study of the whole genome of an organism. Using bioinformatics and high-performance computing, genomic researchers examined massive amounts of deoxyribonucleic acid (DNA)-sequence data to discover variations or mutations that affect drug response, health, or disease. Genomics is a much younger discipline than genetics, having only emerged in the last few decades as a result of technological advancements in DNA sequencing and computational biology.

Question

High throughput whole genome sequencing, RNA-seq and ChIP-seq have all
been made possible by the advent of next generation sequencing (NGS)
technology. Explain these technologies and provide examples of how they
have been used to better understand gene function and gene regulation.

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