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- . Figure 18-14 presents haplotype data for the G6PD genein a worldwide sample of people.a. Draw a haplotype network for these haplotypes.Label the branches on which each SNP occurs.b. Which of the haplotypes has the most connectionsto other haplotypes?c. On what continents is this haplotype found?d. Counting the number of SNPs along the branchesof your network, how many differences are therebetween haplotypes 1 and 12?Explain why we use both Giemsa and DAPI when studying human genetics, and not just one or the other. How are they similar, and how are they different?Part A: If the two genes are 30 mu apart and the plant is (AB/ab), what proportion of gametes from a single plant will be AB? Enter your answer as a decimal to three places (for example: 0.120). Part B: If the two genes are 30 mu apart and the plant is (AB/ab), what proportion of gametes from a single plant will be Ab? Part C: If the two genes are 30 mu apart and the plant is (AB/ab), what proportion of gametes from a single plant will be aB? Part D: If the two genes are 30 mu apart and the plant is (AB/ab), what proportion of gametes from a signal plant will be ab?
- . Consider the genotypes of two lines of chickens: thepure-line mottled Honduran is i/i ; D/D ; M/M ; W/W, andthe pure-line leghorn is I/I ; d/d ; m/m ; w/w, whereI = white feathers, i = colored feathersD = duplex comb, d = simplex combM = bearded, m = beardlessW = white skin, w = yellow skinThese four genes assort independently. Starting withthese two pure lines, what is the fastest and mostconvenient way of generating a pure line that has coloredfeathers, has a simplex comb, is beardless, and has yellowskin? Make sure that you showa. the breeding pedigree.b. the genotype of each animal represented.c. how many eggs to hatch in each cross, and why thisnumber.d. why your scheme is the fastest and the mostconvenientNotation: D = disease allele at gene d = wild-type allele at gene Let’s provide some information about each MOI. AD: Each of the F1 parents is heterozygous for the D allele. SLR: The observed F2 data are the offspring from an F1 cross where the father is affected (disease) and the mother is an unaffected carrier (wild-type, or WT). That is, the mother’s genotype has one disease allele and one WT allele in it. In Table 1, I provide the observed data counts (in dark blue). Notice that I stratify by gender. Table 1 Phenotype O E O-E (O-E)^2 (O-E)^2 /E Disease, Male 304 Disease, Female 267 WT, Male 285 WT, Female 301 Total 1157 DF p-value In Table 2, provide expected proportions for two different MOIs: AD and SLR. The values in this table are computed using information from the Punnett Square and the specified MOI. Once the proportions are determined, we can fill in the values in Table 3, E(xpected)…The gel image below shows 7 alleles, let’s call them 1-7 in order of size, with 1 being the largest and 7 being the smallest. In this sample of 11 individuals, how many times does allele 5 appear?
- I have seen that this was answered as C, Why is the answer C, how is that not evidence of it being genetic? Shouldnt it be none of the above? Question: Of the following, which supports the idea that alcoholism has no genetic or a low genetic component? a) Some strains of mice select alcohol over water 75% of the time, whereas others shun alcohol. b) The concordance value is 55% for MZ twins and 28% for DZ twins. c) Biological sons of alcoholic men who have been adopted have a rate of alcoholism more like that of their adoptive fathers. d) There is a 20% to 25% risk of alcoholism in the sons of alcoholic men. e) None of these.You have the following DNA coding sequence of a wild-type allele: 5’-ATG TTC CAG CTA GAT GAT ATG CTG GTA ATT GGG GAA CGC GCG CGG TAA-3’ 1. For the second, third, fourth, and fifth codons, write all possible anticodon sequences (left-to-right, 5’-3’), including anticodons with wobble and inosine. 2. Write the amino acid sequence of the wild-type allele (three letter or single-letter amino acid abbreviation ok). 3. For each of the following mutations: A. State whether the mutation is missense, nonsense, frameshift, or silent. B. Write the codon change that occurs for the missense, nonsense, and silent mutations (ex. GAA GAT). C. For frameshift mutations, write out the entire mutant sequence with each codon clearly indicated (if the frameshift creates a new stop codon, end the sequence at the new stop). D. Write the amino acid sequence of the mutants. Mutant 1: transition at nucleotide 23 Mutant 2: TG transversion at nucleotide 29 Mutant 3: an insertion of “A” after nucleotide 14…A researcher studied six independently assorting genes in a plant. Each gene has a dominant and a recessive allele: R black stem, r red stem; D tall plant, d dwarf plant; C full pods, c constricted pods; O round fruit, o oval fruit; H hairless leaves, h hairy leaves; W purple flower, w white flower From the cross (P1) RrDdccOoHhWw x (P2) RrddCcooHhww, determine: Note: RrDdccOoHhWw is one genotype. a. How many kinds of gametes can be formed by P1?b. How many genotypes are possible among the progeny of this cross?c. How many phenotypes are possible among the progeny?d. What is the probability of obtaining the RrDdccOohhww genotype in the progeny?e. What is the probability of obtaining a black, dwarf, constricted, oval, hairy, purple phenotype in the progeny?
- Consider the case of a hypothetical genetic disease called WhySciEleven (WSE), an inherited disease that results to the inability to complete production of an amino acid “moduleactivity” that results in brain damage if untreated. WSE is due to a recessive allele. Given one WSE occurrence per 10,000 births. Which term in the Hardy-Weinberg equation corresponds to the frequency of individuals who have no alleles for the disease WSE? a. p b. 2pq c. p2 d. q2Cross Cross A Cross A Cross B Cross B Phenotype F1 generation F2 generation F1 generation F2 generation Male red eyes 132 150 0 99 Female red eyes 135 295 110 101 Male white eyes 0 147 105 93 Female white eyes 0 0 0 95 Using “+” to indicate the wildtype red-eyed allele and “w” to indicate the mutant white-eyed allele, state the genotypes of the following: Wildtype red-eyed and white-eyed parental flies from cross A and cross B. Males and females from the F1 generation flies from cross A and cross B Males and females, F2 generation flies from cross A and cross B.E. W. Lindstrom crossed two corn plants with green seedlings and obtained the following progeny: 3583 green seedlings, 853 virescentwhite seedlings, and 260 yellow seedlings (E. W. Lindstrom. 1921. Genetics 6:91–110). a. Give the genotypes for the green, virescent-white, and yellow progeny. b. Explain how color is determined in these seedlings. c. Is there epistasis among the genes that determine color in the corn seedlings? If so, which gene is epistatic and which is hypostatic?